| pubmed-article:16935861 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16935861 | lifeskim:mentions | umls-concept:C0019693 | lld:lifeskim |
| pubmed-article:16935861 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:16935861 | lifeskim:mentions | umls-concept:C0282114 | lld:lifeskim |
| pubmed-article:16935861 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:16935861 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16935861 | lifeskim:mentions | umls-concept:C1419210 | lld:lifeskim |
| pubmed-article:16935861 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:16935861 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16935861 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16935861 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16935861 | pubmed:issue | 45 | lld:pubmed |
| pubmed-article:16935861 | pubmed:dateCreated | 2006-11-6 | lld:pubmed |
| pubmed-article:16935861 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:abstractText | A novel 2986-base transcript encoded by the antisense strand of the HRES-1 human endogenous retrovirus was isolated from peripheral blood lymphocytes. This transcript codes for a 218-amino acid protein, termed HRES-1/Rab4, based on homology to the Rab4 family of small GTPases. Antibody 13407 raised against recombinant HRES-1/Rab4 detected a native protein of identical molecular weight in human T cells. HRES-1 nucleotides 2151-1606, located upstream of HRES-1/Rab4 exon 1, have promoter activity when oriented in the direction of HRES-1/Rab4 transcription. The human immunodeficiency virus, type 1 (HIV-1), tat gene stimulates transcriptional activity of the HRES-1/Rab4 promoter via trans-activation of the HRES-1 long terminal repeat. Transfection of HIV-1 tat into HeLa cells or infection of H9 and Jurkat cells by HIV-1 increased HRES-1/Rab4 protein levels. Overexpression of HRES-1/Rab4 in Jurkat cells abrogated HIV infection, gag p24 production, and apoptosis, whereas dominant-negative HRES-1/Rab4(S27N) had the opposite effects. HRES-1/Rab4 inhibited surface expression of CD4 and targeted it for lysosomal degradation. HRES-1/Rab4(S27N) enhanced surface expression, recycling, and total cellular CD4 content. Infection by HIV elicited a coordinate down-regulation of CD4 and up-regulation of HRES-1/Rab4 in PBL. Moreover, overexpression of HRES-1/Rab4 reduced CD4 expression on peripheral blood CD4+ T cells. Stimulation by HIV-1 of HRES-1/Rab4 expression and its regulation of CD4 recycling reveal novel coordinate interactions between an infectious retrovirus and the human genome. | lld:pubmed |
| pubmed-article:16935861 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16935861 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16935861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16935861 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16935861 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16935861 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:GergelyPeterP... | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:NilandBrianB | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:BankiKatalinK | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:PerlAndrasA | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:MosserDick... | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:SpivaFloyd... | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:NagyGyorgyG | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:KonczAgnesA | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:FernandezDavi... | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:GrossmanCraig... | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:StancatoChris... | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:WardJeffreyJ | lld:pubmed |
| pubmed-article:16935861 | pubmed:author | pubmed-author:TelaricoTiffa... | lld:pubmed |
| pubmed-article:16935861 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16935861 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:16935861 | pubmed:volume | 281 | lld:pubmed |
| pubmed-article:16935861 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16935861 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16935861 | pubmed:pagination | 34574-91 | lld:pubmed |
| pubmed-article:16935861 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:meshHeading | pubmed-meshheading:16935861... | lld:pubmed |
| pubmed-article:16935861 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16935861 | pubmed:articleTitle | Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection. | lld:pubmed |
| pubmed-article:16935861 | pubmed:affiliation | Department of Medicine, State University of New York, College of Medicine, Syracuse, New York 13210, USA. | lld:pubmed |
| pubmed-article:16935861 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16935861 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16935861 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:5867 | entrezgene:pubmed | pubmed-article:16935861 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16935861 | lld:entrezgene |
| lhgdn:association:23785 | lhgdn:found_in | pubmed-article:16935861 | lld:lhgdn |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16935861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16935861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16935861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16935861 | lld:pubmed |
