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| pubmed-article:1693435 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:1693435 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:1693435 | lifeskim:mentions | umls-concept:C0031751 | lld:lifeskim |
| pubmed-article:1693435 | lifeskim:mentions | umls-concept:C2825311 | lld:lifeskim |
| pubmed-article:1693435 | lifeskim:mentions | umls-concept:C0681828 | lld:lifeskim |
| pubmed-article:1693435 | lifeskim:mentions | umls-concept:C1706209 | lld:lifeskim |
| pubmed-article:1693435 | lifeskim:mentions | umls-concept:C2349209 | lld:lifeskim |
| pubmed-article:1693435 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:1693435 | lifeskim:mentions | umls-concept:C0055367 | lld:lifeskim |
| pubmed-article:1693435 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1693435 | pubmed:dateCreated | 1990-7-12 | lld:pubmed |
| pubmed-article:1693435 | pubmed:abstractText | A monoclonal antibody-dextran-Sn(IV) chlorin e6 immunoconjugate was prepared by a technique involving the site-specific covalent modification of the monoclonal antibody oligosaccharide moiety. Dextran carriers were synthesized with a single chain-terminal hydrazide group, which was used as the coupling point between the carrier and the monoclonal antibody carbohydrate. Selective in vitro photolysis of SK-MEL-2 human malignant melanoma cells was accomplished using several conjugates prepared from anti-melanoma 2.1 (chromophore:antibody molar ratios, 6.8 and 11.2). Phototoxicity, as measured by clonogenic assay, was dependent on the delivered dose of 634-nm light and was observed only for conjugates that bound SK-MEL-2 cells. As judged by competitive inhibition radioimmunoassay, conjugates prepared in this fashion showed excellent retention of antigen binding activity relative to the unmodified antibody. | lld:pubmed |
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| pubmed-article:1693435 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1693435 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1693435 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1693435 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1693435 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1693435 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1693435 | pubmed:author | pubmed-author:YarmushM LML | lld:pubmed |
| pubmed-article:1693435 | pubmed:author | pubmed-author:TompkinsR GRG | lld:pubmed |
| pubmed-article:1693435 | pubmed:author | pubmed-author:RakestrawS... | lld:pubmed |
| pubmed-article:1693435 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1693435 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:1693435 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1693435 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1693435 | pubmed:pagination | 4217-21 | lld:pubmed |
| pubmed-article:1693435 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1693435 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1693435 | pubmed:articleTitle | Antibody-targeted photolysis: in vitro studies with Sn(IV) chlorin e6 covalently bound to monoclonal antibodies using a modified dextran carrier. | lld:pubmed |
| pubmed-article:1693435 | pubmed:affiliation | Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08855-0909. | lld:pubmed |
| pubmed-article:1693435 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1693435 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1693435 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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