Linked Life Data

16931647

Source:http://linkedlifedata.com/resource/pubmed/id/16931647

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-1-1
pubmed:abstractText
It has long been known that central opioid systems play an important role in certain aspects of appetite and food intake, particularly with regard to the hedonic or rewarding impact of calorically dense food, such as fat and sugar. Ventral striatal enkephalin may be a key component of this system, as infusions of mu-opiate agonists into this region strongly increase feeding, whereas infusions of opiate antagonists decrease food intake. While pharmacological analysis has consistently supported such a role, direct measurement of enkephalin gene expression in relation to differing food motivational conditions has not been examined. In this study, the effects of a restricted laboratory chow diet (resulting in negative energy balance) as well has recent consumption of chow (short-term satiety) on striatal preproenkephalin (PPE) and prodynorphin (PD) mRNA expression were measured in rats, using both Northern blot analysis and in situ hybridization methods. As a comparison, hypothalamic (arcuate nucleus) neuropeptide Y (NPY) was also measured in these conditions. PPE expression was broadly downregulated throughout the striatum in animals that had recently consumed a meal, whereas it was unaffected by negative energy balance. Expression of an additional striatal peptide gene, PD, did not follow this pattern, although diet restriction caused a decrease in accumbens core dynorphin mRNA. Conversely, as expected, arcuate nucleus NPY mRNA expression was markedly upregulated by negative energy balance, but was unchanged by recent food consumption. This double dissociation between striatal and hypothalamic peptide systems suggests a specific role for striatal PPE in relatively short-term food motivational states, but not in long-term metabolic responses to diet restriction.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
292
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R217-26
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:16931647-Animals, pubmed-meshheading:16931647-Arcuate Nucleus, pubmed-meshheading:16931647-Blotting, Northern, pubmed-meshheading:16931647-Energy Metabolism, pubmed-meshheading:16931647-Enkephalins, pubmed-meshheading:16931647-Food Deprivation, pubmed-meshheading:16931647-Gene Expression, pubmed-meshheading:16931647-Hunger, pubmed-meshheading:16931647-Hypothalamus, pubmed-meshheading:16931647-In Situ Hybridization, pubmed-meshheading:16931647-Male, pubmed-meshheading:16931647-Motivation, pubmed-meshheading:16931647-Neostriatum, pubmed-meshheading:16931647-Neuropeptide Y, pubmed-meshheading:16931647-Opioid Peptides, pubmed-meshheading:16931647-Protein Precursors, pubmed-meshheading:16931647-RNA, Messenger, pubmed-meshheading:16931647-Rats, pubmed-meshheading:16931647-Rats, Sprague-Dawley, pubmed-meshheading:16931647-Satiety Response
pubmed:year
2007
pubmed:articleTitle
Striatal opioid peptide gene expression differentially tracks short-term satiety but does not vary with negative energy balance in a manner opposite to hypothalamic NPY.
pubmed:affiliation
Department of Psychiatry, University of Wisconsin-Madison Medical School, 6001 Research Park Blvd., Madison, WI 53719, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural