Source:http://linkedlifedata.com/resource/pubmed/id/16931007
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
21
|
| pubmed:dateCreated |
2006-9-25
|
| pubmed:abstractText |
A new series of potent 8-hydroxyquinolines was designed based on the newly resolved X-ray crystal structure of EGLN-1. Both alkyl and aryl 8-hydroxyquinoline-7-carboxyamides were good HIF-1alpha prolyl hydroxylase (EGLN) inhibitors. In subsequent VEGF induction assays, these exhibited potent VEGF activity. In addition, this class of compounds did show the ability to stabilize HIF-1alpha.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0960-894X
|
| pubmed:author |
pubmed-author:BoyerAngeliqueA,
pubmed-author:EvdokimovArtem GAG,
pubmed-author:KawamotoRichardR,
pubmed-author:MekelMarleneM,
pubmed-author:PokrossMatthewM,
pubmed-author:RenockSeanS,
pubmed-author:ShevilleJustinJ,
pubmed-author:WalterRichardR,
pubmed-author:WarshakoonNamal CNC,
pubmed-author:WinterCarolC,
pubmed-author:WuShengdeS,
pubmed-author:XuKevinK,
pubmed-author:ZhouSongtaoS
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5517-22
|
| pubmed:meshHeading | |
| pubmed:year |
2006
|
| pubmed:articleTitle |
Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.
|
| pubmed:affiliation |
Drug Discovery Division, Procter and Gamble Pharmaceuticals Inc., 8700 Mason-Montgomery Road, Mason, OH 45040, USA. Warshakoon.nc@pg.com
|
| pubmed:publicationType |
Journal Article
|