Source:http://linkedlifedata.com/resource/pubmed/id/16930943
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-12-5
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| pubmed:abstractText |
Sulthiame is a carbonic anhydrase inhibitor that is widely used to treat partial and myoclonic seizures. In 11 healthy adults, we applied transcranial magnetic stimulation (TMS) to the primary motor cortex. Using a cross-over study design, we found that a single oral dose of sulthiame (5 mg/kg) produced a significant increase of resting motor threshold relative to placebo. No other TMS measure of corticomotor excitability was altered after a single dose of sulthiame. The selective increase in motor threshold suggests that sulthiame produces its antiepileptic effect by reducing the axonal excitability of cortical neurons.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0920-1211
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
72
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
18-24
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| pubmed:meshHeading |
pubmed-meshheading:16930943-Administration, Oral,
pubmed-meshheading:16930943-Adult,
pubmed-meshheading:16930943-Anticonvulsants,
pubmed-meshheading:16930943-Cerebral Cortex,
pubmed-meshheading:16930943-Cross-Over Studies,
pubmed-meshheading:16930943-Female,
pubmed-meshheading:16930943-Humans,
pubmed-meshheading:16930943-Male,
pubmed-meshheading:16930943-Thiazines,
pubmed-meshheading:16930943-Transcranial Magnetic Stimulation
|
| pubmed:year |
2006
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| pubmed:articleTitle |
A single dose of sulthiame induces a selective increase in resting motor threshold in human motor cortex: A transcranial magnetic stimulation study.
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| pubmed:affiliation |
Neuropediatric Department, Christian-Albrechts-University, Kiel, Germany. m.siniatchkin@pedneuro.uni-kiel.de
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| pubmed:publicationType |
Journal Article
|