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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0014544,
umls-concept:C0026336,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0152314,
umls-concept:C0205147,
umls-concept:C0205349,
umls-concept:C0439849,
umls-concept:C0443199,
umls-concept:C0445223,
umls-concept:C0597879,
umls-concept:C0871261,
umls-concept:C1413038,
umls-concept:C1552599,
umls-concept:C1704632,
umls-concept:C1704787,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2006-10-2
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pubmed:abstractText |
The epileptic hippocampus shows differential paired-pulse responses between the dentate gyrus and the CA1 region. However, little data are available to explain this phenomenon. In the present study, we identified the relationship between regional differences of paired-pulse response and voltage gated Cl(-) channel 2 (CLC-2)/vesicular GABA transport (VGAT) expression in a pilocarpine-induced rat model. During epileptogenic periods, paired-pulse inhibitions in the dentate gyrus and the CA1 region were markedly reduced. After recurrent seizure onset, paired-pulse inhibition in the dentate gyrus was markedly enhanced, while that in the CA1 region more reduced. Unlike VGAT, CLC-2 immunoreactivity was markedly reduced in the hippocampus during epileptogenic periods and was re-enhanced only in the dentate gyrus after recurrent seizure onset. Linear regression analysis showed an inverse proportional relationship between alterations in CLC-2 immunoreactivity and changes in normalized population spike amplitude ratio within the CA1 region and the dentate gyrus. Therefore, our findings suggest that the regionally specific alterations in CLC-2 immunoreactivity after SE may determine the properties of paired-pulse responses in the hippocampus of the pilocarpine-induced rat epilepsy model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
1115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
162-8
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pubmed:meshHeading |
pubmed-meshheading:16930566-Action Potentials,
pubmed-meshheading:16930566-Animals,
pubmed-meshheading:16930566-Chloride Channels,
pubmed-meshheading:16930566-Convulsants,
pubmed-meshheading:16930566-Dentate Gyrus,
pubmed-meshheading:16930566-Disease Models, Animal,
pubmed-meshheading:16930566-Electric Stimulation,
pubmed-meshheading:16930566-Epilepsy,
pubmed-meshheading:16930566-Hippocampus,
pubmed-meshheading:16930566-Immunohistochemistry,
pubmed-meshheading:16930566-Muscarinic Agonists,
pubmed-meshheading:16930566-Neural Inhibition,
pubmed-meshheading:16930566-Pilocarpine,
pubmed-meshheading:16930566-Rats,
pubmed-meshheading:16930566-Rats, Sprague-Dawley,
pubmed-meshheading:16930566-Synaptic Transmission,
pubmed-meshheading:16930566-Vesicular Inhibitory Amino Acid Transport Proteins,
pubmed-meshheading:16930566-gamma-Aminobutyric Acid
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pubmed:year |
2006
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pubmed:articleTitle |
Differential paired-pulse responses between the CA1 region and the dentate gyrus are related to altered CLC-2 immunoreactivity in the pilocarpine-induced rat epilepsy model.
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pubmed:affiliation |
Department of Anatomy, College of Medicine, Hallym University, Chunchon, Kangwon-Do 200-702, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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