Linked Life Data

16929535

Source:http://linkedlifedata.com/resource/pubmed/id/16929535

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2006-10-18
pubmed:abstractText
Multidrug-resistant (MDR) multiple myeloma (MM) patients who fail chemotherapy frequently express MDR1 protein, which serves as an efflux pump that protects neoplastic cells. The expression of lung resistance protein (LRP), which mediates intercellular and nucleocytoplasmic transport, is also correlated with chemotherapy resistance and shorter survival of MM patients. Here, we investigated the chemotherapy-induced change of MDR expression in MM patients using quantitative RT-PCR. Overall expression levels of MDR1 and LRP in MM patients were significantly higher than those in control subjects and increased after chemotherapy. More than half of the patients exhibited increased expression of MDR1 (14/26) or LRP (17/26) after chemotherapy. Also, the expression of inhibitor of apoptosis proteins (IAP) was determined in association with the prognosis of the patients. Among patients with increased MDR1-expression after chemotherapy, those with a poor outcome exhibited significant increases in survivin, cIAP1, cIAP2, and XIAP expression by chemotherapy compared with those with a good prognosis. Similarly, in the LRP expression-increased group, patients with a poor outcome showed significant increases of cIAP1 and cIAP2 expression compared with those with longer survival. In patients with reduced-MDR1 or LRP expression after chemotherapy, changes in the expression of IAPs induced by chemotherapy did not correlate with their prognosis. These findings indicate that IAP family proteins might play a role in worsening the prognosis of MM patients in association with chemotherapy-induced overexpression of MDR1 or LRP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0361-8609
pubmed:author
pubmed:copyrightInfo
(c) 2006 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
824-31
pubmed:dateRevised
2008-5-14
pubmed:meshHeading
pubmed-meshheading:16929535-Adult, pubmed-meshheading:16929535-Aged, pubmed-meshheading:16929535-Antineoplastic Agents, pubmed-meshheading:16929535-Apoptosis, pubmed-meshheading:16929535-Base Sequence, pubmed-meshheading:16929535-Bone Marrow, pubmed-meshheading:16929535-Cell Division, pubmed-meshheading:16929535-DNA Primers, pubmed-meshheading:16929535-Drug Resistance, Multiple, pubmed-meshheading:16929535-Female, pubmed-meshheading:16929535-Gene Expression Regulation, Neoplastic, pubmed-meshheading:16929535-Humans, pubmed-meshheading:16929535-Inhibitor of Apoptosis Proteins, pubmed-meshheading:16929535-Male, pubmed-meshheading:16929535-Middle Aged, pubmed-meshheading:16929535-Multiple Myeloma, pubmed-meshheading:16929535-P-Glycoprotein, pubmed-meshheading:16929535-RNA, Messenger, pubmed-meshheading:16929535-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16929535-Treatment Outcome, pubmed-meshheading:16929535-X-Linked Inhibitor of Apoptosis Protein
pubmed:year
2006
pubmed:articleTitle
IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes.
pubmed:affiliation
Department of Comprehensive Pathology, Aging and Developmental Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
pubmed:publicationType
Journal Article