Linked Life Data

1692876

Source:http://linkedlifedata.com/resource/pubmed/id/1692876

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-6-25
pubmed:abstractText
The numbers of CD1, HLADR, HLADP and HLADQ positive, intraepithelial, dendritic cells were compared in lesions of oral lichen planus and normal oral mucosa using an immunoalkaline phosphatase technique. In normal mucosa, there were equal numbers of CD1 and HLADR positive cells but significantly fewer cells were positive for HLADP (P less than 0.001) and HLADQ (P less than 0.05). In lichen planus, the cells appeared more dendritic and equal numbers of CD1, HLADR, HLADP and HLADQ positive cells were found, with significantly more HLADP (P less than 0.01) and HLADQ (P less than 0.05) positive cells than in normal mucosa. There was no change in the number of CD1 and HLADR positive cells. These results show that although there is no change in the total number of Langerhans cells (CD1 positive cells) in lichen planus, there is an increase in Class II major histocompatibility antigen expression. This suggests that in lichen planus, Langerhans cells are immunologically active and play a role in lesion development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0904-2512
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
The activation of Langerhans cells in oral lichen planus.
pubmed:affiliation
Department of Oral Pathology, London Hospital Medical College, UK.
pubmed:publicationType
Journal Article