Linked Life Data

1692823

Source:http://linkedlifedata.com/resource/pubmed/id/1692823

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-6-27
pubmed:abstractText
We have been studying human T-cell clones that suppress anti-mycobacterial T-cell responses but not T-cell responses to an unrelated antigen or mitogen. In the present paper we report our studies on the activation requirements of these suppressor-T-cell clones. The suppressor-T-cell clones could proliferate and produce interferon-gamma upon stimulation with Mycobacterium leprae and other mycobacteria but not with unrelated antigens or autologous T cells. Both suppressor and nonsuppressor clones react to a 36-kDa antigen of M. leprae. Thus far, we have not been able to demonstrate whether they see the same or different epitopes. The antigen-driven proliferation of suppressor-T-cell clones was, however, significantly lower than that observed for T-cell clones that did not mediate suppression. The proliferation of suppressor-T-cell clones to M. leprae antigens could be blocked by monoclonal antibodies to HLA-DR, alpha beta T-cell receptor, interleukin-2 receptor, and, in the case of CD4-positive suppressor-T-cell clones, anti-CD4 monoclonal antibodies. DR restriction of the antigen presentation to these suppressor-T-cell clones was shown in mixing experiments using antigen-presenting cells as mononuclear cells from family members and unrelated individuals. These experiments also indicated that apart from regular DR-restriction a hitherto unknown factor may be required for presentation to or activation of suppressor-T-cell clones that is present in the family members and unrelated individuals with the same ethnic and geographic background but absent in DR/Dw-matched healthy Dutch individuals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0198-8859
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-26
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:1692823-Antibodies, Monoclonal, pubmed-meshheading:1692823-Antigen-Presenting Cells, pubmed-meshheading:1692823-Antigens, Bacterial, pubmed-meshheading:1692823-Antigens, CD4, pubmed-meshheading:1692823-CD4-Positive T-Lymphocytes, pubmed-meshheading:1692823-Cell Division, pubmed-meshheading:1692823-Clone Cells, pubmed-meshheading:1692823-Epitopes, pubmed-meshheading:1692823-HLA-DR Antigens, pubmed-meshheading:1692823-Humans, pubmed-meshheading:1692823-Interferon-gamma, pubmed-meshheading:1692823-Interleukin-2, pubmed-meshheading:1692823-Leprosy, Borderline, pubmed-meshheading:1692823-Lymphocyte Activation, pubmed-meshheading:1692823-Mycobacterium leprae, pubmed-meshheading:1692823-Phenotype, pubmed-meshheading:1692823-Receptors, Antigen, T-Cell, pubmed-meshheading:1692823-Receptors, Antigen, T-Cell, alpha-beta, pubmed-meshheading:1692823-T-Lymphocytes, Regulatory
pubmed:year
1990
pubmed:articleTitle
Phenotypic and functional characterization of human suppressor T-cell clones: II. Activation by Mycobacterium leprae presented by HLA-DR molecules to alpha beta T-cell receptors.
pubmed:affiliation
Department of Immunohaematology and Blood Bank, University Hospital, Leiden, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't