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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2006-9-27
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pubmed:abstractText |
Alterations of fibroblast growth factors and their receptors contribute to prostate cancer progression by enhancing cell survival, motility, and proliferation. The expression of the FGFR-4 Arg(388) variant is correlated with the occurrence of pelvic lymph node metastasis and biochemical (PSA) recurrence in men undergoing radical prostatectomy. Ehm2 is an androgen-regulated gene that has been associated with metastasis in other systems, so we sought to determine if it is expressed in prostate cancer and if the FGFR-4 Arg(388) variant can increase its expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1641-52
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16927306-Adenocarcinoma,
pubmed-meshheading:16927306-Cell Adhesion,
pubmed-meshheading:16927306-Cell Line, Transformed,
pubmed-meshheading:16927306-Cell Line, Tumor,
pubmed-meshheading:16927306-Cytoskeletal Proteins,
pubmed-meshheading:16927306-Dihydrotestosterone,
pubmed-meshheading:16927306-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16927306-Humans,
pubmed-meshheading:16927306-In Situ Hybridization,
pubmed-meshheading:16927306-Lymphatic Metastasis,
pubmed-meshheading:16927306-Male,
pubmed-meshheading:16927306-Neoplasm Recurrence, Local,
pubmed-meshheading:16927306-Prostate,
pubmed-meshheading:16927306-Prostatectomy,
pubmed-meshheading:16927306-Prostatic Neoplasms,
pubmed-meshheading:16927306-Receptor, Fibroblast Growth Factor, Type 4,
pubmed-meshheading:16927306-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16927306-Tissue Array Analysis,
pubmed-meshheading:16927306-Up-Regulation
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pubmed:year |
2006
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pubmed:articleTitle |
Increased expression of the metastasis-associated gene Ehm2 in prostate cancer.
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pubmed:affiliation |
Department of Pathology of Baylor College of Medicine and Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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