| pubmed-article:16925584 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16925584 | lifeskim:mentions | umls-concept:C0242643 | lld:lifeskim |
| pubmed-article:16925584 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:16925584 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:16925584 | lifeskim:mentions | umls-concept:C0687676 | lld:lifeskim |
| pubmed-article:16925584 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:16925584 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16925584 | pubmed:dateCreated | 2006-10-12 | lld:pubmed |
| pubmed-article:16925584 | pubmed:abstractText | The human multidrug resistance gene 1 (MDR1) encodes the plasma membrane P-glycoprotein (P-gp/ABCB1) that functions as an efflux pump for various anticancer agents. We recently reported that estrogens down-regulate the expression of breast cancer resistance protein (BCRP/ABCG2). In our present study we demonstrate that estrogens also down-regulate P-gp expression in the MDR1-transduced, estrogen receptor alpha (ER-alpha)-positive human breast cancer cells, MCF-7/MDR and T-47D/MDR. The P-gp expression levels in MCF-7/MDR cells treated with 100 pM estradiol were found to be 10-20-fold lower than the levels in these same cells that were cultured without estradiol. In contrast, estradiol did not affect the P-gp expression levels in the ER-alpha-negative cancer cells, MDA-MB-231/MDR and NCI/ADR-RES. Estrone and diethylstilbestrol were also found to down-regulate P-gp in MCF-7/MDR cells, but progesterone treatment did not produce this effect. Tamoxifen reversed the estradiol-mediated down-regulation of P-gp in MCF-7/MDR cells, suggesting that ER-alpha activity is necessary for the effects of estradiol upon P-gp. However, estradiol was found not to alter the MDR1 transcript levels in either MCF-7/MDR and T-47D/MDR cells, suggesting that post-transcriptional mechanisms underlie its effects upon P-gp down-regulation. MCF-7/MDR cells also showed eight-fold higher sensitivity to vincristine when treated with 100 pM estradiol, than when treated with 1 pM estradiol. These results may serve to provide a better understanding of the expression control of ABC transporters, and possibly allow for the establishment of new cancer chemotherapy strategies that would control P-gp expression in breast cancer cells and thereby increase their sensitivity to MDR1-related anticancer agents. | lld:pubmed |
| pubmed-article:16925584 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16925584 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16925584 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16925584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16925584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16925584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16925584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16925584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16925584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16925584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16925584 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16925584 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16925584 | pubmed:issn | 1347-9032 | lld:pubmed |
| pubmed-article:16925584 | pubmed:author | pubmed-author:TsukaharaSato... | lld:pubmed |
| pubmed-article:16925584 | pubmed:author | pubmed-author:SugimotoYoshi... | lld:pubmed |
| pubmed-article:16925584 | pubmed:author | pubmed-author:KatayamaKazuh... | lld:pubmed |
| pubmed-article:16925584 | pubmed:author | pubmed-author:MitsuhashiJun... | lld:pubmed |
| pubmed-article:16925584 | pubmed:author | pubmed-author:MutohKazuyosh... | lld:pubmed |
| pubmed-article:16925584 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16925584 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:16925584 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16925584 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16925584 | pubmed:pagination | 1198-204 | lld:pubmed |
| pubmed-article:16925584 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:meshHeading | pubmed-meshheading:16925584... | lld:pubmed |
| pubmed-article:16925584 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16925584 | pubmed:articleTitle | Estrogen-mediated post transcriptional down-regulation of P-glycoprotein in MDR1-transduced human breast cancer cells. | lld:pubmed |
| pubmed-article:16925584 | pubmed:affiliation | Department of Chemotherapy, Kyoritsu University of Pharmacy, 1-5-30 Shibakoen, Minatoku, Tokyo 105-8512, Japan. | lld:pubmed |
| pubmed-article:16925584 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16925584 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16925584 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16925584 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16925584 | lld:pubmed |
