Source:http://linkedlifedata.com/resource/pubmed/id/16924569
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-8-22
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| pubmed:abstractText |
There are still uncertainties as to the mechanism of many pathological conditions, among them allergic diseases. It has been suggest that acetylation rate may be a factor that influences the development of allergic diseases. The aim of the present study was to investigate further whether the genetic polymorphism of the NAT2 plays a role in susceptibility to bronchial asthma disease. Ninety-seven patients with bronchial asthma (atopic n= 62; non-atopic n= 35) and 104 healthy individuals were participated in this study. DNA was extracted from the leucocyte by high pure template preparation kit. NAT2*5A, NAT2*6A, NAT2*7A/B and NAT2*14A polymorphisms of NAT2 were detected by using LightCycler-NAT2 mutation detection kit by real time PCR with LightCycler instrument. We found that mutant NAT2*5A (OR= 3.84, 95% CI= 1.08-13.6) and NAT2*6A (OR= 5.27, 95% CI= 1.06-26.05) genotype could be associated with a high risk for the development of bronchial asthma according to the genotype. After grouping phenotype, the risk for bronchial asthma was more than two times higher (OR= 2.7, 95% CI= 1.07-6.97) in individuals with the slow NAT2*5A acetylator phenotype compared to the fast phenotype. Our study suggests that the NAT2 slow acetylators may be a determinant in susceptibility to asthma disease. This finding may have implications for the theories for the pathogenesis of the disease as well as for therapeutic aspects.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0494-1373
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
54
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
137-43
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| pubmed:dateRevised |
2008-8-5
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| pubmed:meshHeading |
pubmed-meshheading:16924569-Acetyltransferases,
pubmed-meshheading:16924569-Asthma,
pubmed-meshheading:16924569-Case-Control Studies,
pubmed-meshheading:16924569-European Continental Ancestry Group,
pubmed-meshheading:16924569-Female,
pubmed-meshheading:16924569-Genetic Predisposition to Disease,
pubmed-meshheading:16924569-Humans,
pubmed-meshheading:16924569-Male,
pubmed-meshheading:16924569-Middle Aged,
pubmed-meshheading:16924569-Mutation,
pubmed-meshheading:16924569-Polymorphism, Genetic,
pubmed-meshheading:16924569-Risk Factors,
pubmed-meshheading:16924569-Turkey
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| pubmed:year |
2006
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| pubmed:articleTitle |
Relationship between N-acetyl transferase-2 gene polymorphism and risk of bronchial asthma.
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| pubmed:affiliation |
Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey. lutamer@yahoo.com
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| pubmed:publicationType |
Journal Article
|