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rdf:type |
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lifeskim:mentions |
umls-concept:C0026336,
umls-concept:C0030163,
umls-concept:C0037189,
umls-concept:C0039082,
umls-concept:C0178611,
umls-concept:C0392756,
umls-concept:C0439799,
umls-concept:C0439857,
umls-concept:C1515655,
umls-concept:C1517499,
umls-concept:C1537647,
umls-concept:C2827421
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pubmed:issue |
10
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pubmed:dateCreated |
2006-9-5
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pubmed:abstractText |
The normal cardiac rhythm originates in the sinoatrial (SA) node that anatomically resides in the right atrium. Malfunction of the SA node leads to various forms of arrhythmias that necessitate the implantation of electronic pacemakers. We hypothesized that overexpression of an engineered HCN construct via somatic gene transfer offers a flexible approach for fine-tuning cardiac pacing in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1000-11
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16923751-Animals,
pubmed-meshheading:16923751-Arrhythmias, Cardiac,
pubmed-meshheading:16923751-Bioartificial Organs,
pubmed-meshheading:16923751-Cyclic Nucleotide-Gated Cation Channels,
pubmed-meshheading:16923751-Disease Models, Animal,
pubmed-meshheading:16923751-Electrophysiology,
pubmed-meshheading:16923751-Gene Transfer Techniques,
pubmed-meshheading:16923751-Guinea Pigs,
pubmed-meshheading:16923751-Heart Rate,
pubmed-meshheading:16923751-Ion Channels,
pubmed-meshheading:16923751-Mice,
pubmed-meshheading:16923751-Pacemaker, Artificial,
pubmed-meshheading:16923751-Potassium Channels,
pubmed-meshheading:16923751-Sick Sinus Syndrome,
pubmed-meshheading:16923751-Sinoatrial Node,
pubmed-meshheading:16923751-Swine,
pubmed-meshheading:16923751-Swine, Miniature
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pubmed:year |
2006
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pubmed:articleTitle |
Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model.
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pubmed:affiliation |
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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