|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005821,
umls-concept:C0026882,
umls-concept:C0030705,
umls-concept:C0031715,
umls-concept:C0040028,
umls-concept:C0205210,
umls-concept:C0449438,
umls-concept:C0936012,
umls-concept:C1335875,
umls-concept:C1705050,
umls-concept:C1707520,
umls-concept:C2348519
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2006-8-22
|
|
pubmed:abstractText |
JAK2V617F mutation rate in granulocytes from essential thrombocythemia (ET) patients ranges from 12% to 57%. Our aim was to evaluate the frequency of this mutation in the megakaryocyte/platelet lineage, and to analyze its clinical associations in ET. In addition, we determined whether this mutation leads to constitutive phosphorylation of STAT5 in platelets.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0902-4441
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
77
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
210-6
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16923108-Adolescent,
pubmed-meshheading:16923108-Adult,
pubmed-meshheading:16923108-Aged,
pubmed-meshheading:16923108-Aged, 80 and over,
pubmed-meshheading:16923108-Amino Acid Substitution,
pubmed-meshheading:16923108-Base Sequence,
pubmed-meshheading:16923108-Blood Platelets,
pubmed-meshheading:16923108-Child,
pubmed-meshheading:16923108-DNA, Complementary,
pubmed-meshheading:16923108-Female,
pubmed-meshheading:16923108-Gene Frequency,
pubmed-meshheading:16923108-Humans,
pubmed-meshheading:16923108-Janus Kinase 2,
pubmed-meshheading:16923108-Male,
pubmed-meshheading:16923108-Middle Aged,
pubmed-meshheading:16923108-Phosphorylation,
pubmed-meshheading:16923108-Point Mutation,
pubmed-meshheading:16923108-Protein-Tyrosine Kinases,
pubmed-meshheading:16923108-Proto-Oncogene Proteins,
pubmed-meshheading:16923108-RNA,
pubmed-meshheading:16923108-STAT5 Transcription Factor,
pubmed-meshheading:16923108-Thrombocythemia, Essential
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
JAK2V617F mutation in platelets from essential thrombocythemia patients: correlation with clinical features and analysis of STAT5 phosphorylation status.
|
|
pubmed:affiliation |
Hematología Investigación, Instituto de Investigaciones Médicas A. Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina. idimhematologia@hotmail.com
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
