| pubmed-article:16921068 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16921068 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:16921068 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:16921068 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:16921068 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:16921068 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:16921068 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16921068 | pubmed:dateCreated | 2006-9-29 | lld:pubmed |
| pubmed-article:16921068 | pubmed:abstractText | The 3'-untranslated regions (UTRs) of a group of novel uncapped viral RNAs allow efficient translation initiation at the 5'-proximal AUG. A well-characterized model is the Barley yellow dwarf virus class of cap-independent translation elements (BTE). It facilitates translation by forming kissing stem-loops between the BTE in the 3'-UTR and a BTE-complementary loop in the 5'-UTR. Here we investigate the mechanisms of the long-distance interaction and ribosome entry on the RNA. Upstream AUGs or 5'-extensions of the 5'-UTR inhibit translation, indicating that, unlike internal ribosome entry sites in many viral RNAs, the BTE relies on 5'-end-dependent ribosome scanning. Cap-independent translation occurs when the kissing sites are moved to different regions in either UTR, including outside of the BTE. The BTE can even confer cap-independent translation when fused to the 3'-UTR of a reporter RNA harboring dengue virus sequences that cause base-pairing between the 3'- and 5'-ends. Thus, the BTE serves as a functional sensor to detect sequences capable of long-distance base-pairing. We propose that the kissing interaction is repeatedly disrupted by the scanning ribosome and re-formed in an oscillating process that regulates ribosome entry on the RNA. | lld:pubmed |
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| pubmed-article:16921068 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16921068 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16921068 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16921068 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16921068 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16921068 | pubmed:issn | 1355-8382 | lld:pubmed |
| pubmed-article:16921068 | pubmed:author | pubmed-author:MillerW... | lld:pubmed |
| pubmed-article:16921068 | pubmed:author | pubmed-author:HarrisEvaE | lld:pubmed |
| pubmed-article:16921068 | pubmed:author | pubmed-author:PolacekCharlo... | lld:pubmed |
| pubmed-article:16921068 | pubmed:author | pubmed-author:Rakotondrafar... | lld:pubmed |
| pubmed-article:16921068 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16921068 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:16921068 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16921068 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16921068 | pubmed:pagination | 1893-906 | lld:pubmed |
| pubmed-article:16921068 | pubmed:dateRevised | 2011-6-1 | lld:pubmed |
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| pubmed-article:16921068 | pubmed:meshHeading | pubmed-meshheading:16921068... | lld:pubmed |
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| pubmed-article:16921068 | pubmed:meshHeading | pubmed-meshheading:16921068... | lld:pubmed |
| pubmed-article:16921068 | pubmed:meshHeading | pubmed-meshheading:16921068... | lld:pubmed |
| pubmed-article:16921068 | pubmed:meshHeading | pubmed-meshheading:16921068... | lld:pubmed |
| pubmed-article:16921068 | pubmed:meshHeading | pubmed-meshheading:16921068... | lld:pubmed |
| pubmed-article:16921068 | pubmed:meshHeading | pubmed-meshheading:16921068... | lld:pubmed |
| pubmed-article:16921068 | pubmed:meshHeading | pubmed-meshheading:16921068... | lld:pubmed |
| pubmed-article:16921068 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16921068 | pubmed:articleTitle | Oscillating kissing stem-loop interactions mediate 5' scanning-dependent translation by a viral 3'-cap-independent translation element. | lld:pubmed |
| pubmed-article:16921068 | pubmed:affiliation | Molecular, Cellular, and Developmental Biology Program and Plant Pathology Department, Iowa State University, Ames, Iowa 50011, USA. | lld:pubmed |
| pubmed-article:16921068 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16921068 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16921068 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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