16921068

Source:http://linkedlifedata.com/resource/pubmed/id/16921068

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0013879, umls-concept:C0040711, umls-concept:C0086597, umls-concept:C0521026, umls-concept:C1704675
pubmed:issue	10
pubmed:dateCreated	2006-9-29
pubmed:abstractText	The 3'-untranslated regions (UTRs) of a group of novel uncapped viral RNAs allow efficient translation initiation at the 5'-proximal AUG. A well-characterized model is the Barley yellow dwarf virus class of cap-independent translation elements (BTE). It facilitates translation by forming kissing stem-loops between the BTE in the 3'-UTR and a BTE-complementary loop in the 5'-UTR. Here we investigate the mechanisms of the long-distance interaction and ribosome entry on the RNA. Upstream AUGs or 5'-extensions of the 5'-UTR inhibit translation, indicating that, unlike internal ribosome entry sites in many viral RNAs, the BTE relies on 5'-end-dependent ribosome scanning. Cap-independent translation occurs when the kissing sites are moved to different regions in either UTR, including outside of the BTE. The BTE can even confer cap-independent translation when fused to the 3'-UTR of a reporter RNA harboring dengue virus sequences that cause base-pairing between the 3'- and 5'-ends. Thus, the BTE serves as a functional sensor to detect sequences capable of long-distance base-pairing. We propose that the kissing interaction is repeatedly disrupted by the scanning ribosome and re-formed in an oscillating process that regulates ribosome entry on the RNA.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/GM067104, http://linkedlifedata.com/resource/pubmed/grant/R01 GM067104-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 GM067104-02, http://linkedlifedata.com/resource/pubmed/grant/R01 GM067104-03, http://linkedlifedata.com/resource/pubmed/grant/R01 GM067104-04
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-10376873, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-10516004, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-10559263, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-10766738, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-11142380, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-11250909, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-11389856, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-11413342, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-11445534, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-11502008, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-11804583, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-11878914, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-12149516, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-12435632, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-12459250, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-12824337, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-14512577, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-14581548, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-14729906, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-15020708, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-15078948, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-15123633, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-15164008, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-15189156, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-15367615, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-1546465, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-15476880, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-16166382, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-16246150, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-16307817, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-16322461, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-16327775, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-16360925, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-16364749, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-16449648, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-16545417, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-16647707, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-1939050, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-2601712, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-3575095, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-7378360, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-8486640, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-9233819, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-9261187, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-9372919, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-9628479, http://linkedlifedata.com/resource/pubmed/commentcorrection/16921068-9671055
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9509184
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/3' Untranslated Regions, http://linkedlifedata.com/resource/pubmed/chemical/5' Untranslated Regions, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral, http://linkedlifedata.com/resource/pubmed/chemical/RNA Caps
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	1355-8382
pubmed:author	pubmed-author:HarrisEvaE, pubmed-author:MillerW AllenWA, pubmed-author:PolacekCharlottaC, pubmed-author:RakotondrafaraAurélie MAM
pubmed:issnType	Print
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1893-906
pubmed:dateRevised	2011-6-1
pubmed:meshHeading	pubmed-meshheading:16921068-3' Untranslated Regions, pubmed-meshheading:16921068-5' Untranslated Regions, pubmed-meshheading:16921068-Base Sequence, pubmed-meshheading:16921068-Dengue Virus, pubmed-meshheading:16921068-Luteovirus, pubmed-meshheading:16921068-Models, Biological, pubmed-meshheading:16921068-Molecular Sequence Data, pubmed-meshheading:16921068-Nucleic Acid Conformation, pubmed-meshheading:16921068-Protein Biosynthesis, pubmed-meshheading:16921068-RNA, Viral, pubmed-meshheading:16921068-RNA Caps, pubmed-meshheading:16921068-Ribosomes
pubmed:year	2006
pubmed:articleTitle	Oscillating kissing stem-loop interactions mediate 5' scanning-dependent translation by a viral 3'-cap-independent translation element.
pubmed:affiliation	Molecular, Cellular, and Developmental Biology Program and Plant Pathology Department, Iowa State University, Ames, Iowa 50011, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural