Source:http://linkedlifedata.com/resource/pubmed/id/16921025
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2006-12-1
|
| pubmed:abstractText |
CD69 expression is induced following activation of leukocytes at inflammatory sites and plays a negative regulatory role in the development of collagen-induced arthritis (CIA). To evaluate potential strategies of CD69 targeting in chronic inflammatory diseases, two different anti-CD69 mAbs were generated and their effects on CIA were studied. Administration of the IgG1 anti-CD69 mAb 2.2 to DBA/1 mice with CIA led to an exacerbation of the disease, correlated with down-modulation of CD69 from the cell surface, and reproduced the phenotype of the CD69(-/-) mouse in wild-type animals. In contrast, treatment with the IgG2a anti-CD69 mAb 2.3 was effective in ameliorating CIA when administered in the early or intermediate phases of the disease, causing a decreased production of proinflammatory cytokines in inflammatory foci. Monoclonal antibody 2.3 induces partial depletion of CD69+ cells in vivo. Moreover, adoptive transfer of type-II collagen (CII)-sensitized cells treated with mAb 2.3 to deplete CD69+ cells did not result in arthritis. The attenuation of inflammation correlates with reduced lymphocyte proliferative response in response to CII and with a reduction in the frequency of CII-specific T cells producing IFN-gamma. We thus conclude that CD69 targeting by mAbs can either enhance or dampen the immune response.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0741-5400
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
80
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1233-41
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:16921025-Adoptive Transfer,
pubmed-meshheading:16921025-Animals,
pubmed-meshheading:16921025-Antibodies, Monoclonal,
pubmed-meshheading:16921025-Antigens, CD,
pubmed-meshheading:16921025-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:16921025-Arthritis, Experimental,
pubmed-meshheading:16921025-Cell Proliferation,
pubmed-meshheading:16921025-Collagen Type II,
pubmed-meshheading:16921025-Immunoglobulin G,
pubmed-meshheading:16921025-Inflammation,
pubmed-meshheading:16921025-Interferon-gamma,
pubmed-meshheading:16921025-Lectins, C-Type,
pubmed-meshheading:16921025-Lymphocyte Depletion,
pubmed-meshheading:16921025-Mice,
pubmed-meshheading:16921025-Mice, Inbred BALB C,
pubmed-meshheading:16921025-Mice, Inbred DBA,
pubmed-meshheading:16921025-Mice, Knockout,
pubmed-meshheading:16921025-T-Lymphocytes
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| pubmed:year |
2006
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| pubmed:articleTitle |
CD69 targeting differentially affects the course of collagen-induced arthritis.
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| pubmed:affiliation |
Hospital Universitario de La Princesa,C/ Diego de León, 62, Madrid E-28006, Spain.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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