Source:http://linkedlifedata.com/resource/pubmed/id/16920640
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2006-8-21
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pubmed:abstractText |
Myotonic dystrophies (DM) are repeat expansion diseases in which expanded CTG (DM1) and CCTG (DM2) repeats cause the disease. Mutant transcripts containing CUG/CCUG repeats are retained in muscle nuclei producing ribonuclear inclusions, which can bind specific RNA-binding proteins, leading to a reduction in their activity. The sequestration of muscleblind-like proteins (MBNLs), a family of alternative splicing factors, appears to be involved in splicing defects characteristic of DM pathologies. To determine whether MBNL1 nuclear sequestration is a feature of DM pathologies, we have examined the in vivo distribution of MBNL1 in muscle sections from genetically confirmed DM1 (n=7) and DM2 (n=9) patients, patients with other myotonic disorders (n=11) and from patients with disorders caused by repeat expansions, but not DM1/DM2 (n=3). The results of our immunofluorescence study indicate that, among patients examined, MBNL1 nuclear sequestration in protein foci is a molecular pathology marker of DM1 and DM2 patients where ribonuclear inclusions of transcripts with expanded CUG/CCUG repeats are also present. These findings indicate that MBNLs might be important targets for therapeutic interventions to correct some of the specific features of DM pathology.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1121-760X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
177-82
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pubmed:dateRevised |
2008-8-15
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pubmed:meshHeading |
pubmed-meshheading:16920640-Cell Nucleus,
pubmed-meshheading:16920640-DNA Repeat Expansion,
pubmed-meshheading:16920640-Genetic Markers,
pubmed-meshheading:16920640-Humans,
pubmed-meshheading:16920640-In Situ Hybridization, Fluorescence,
pubmed-meshheading:16920640-Muscle, Skeletal,
pubmed-meshheading:16920640-Myotonic Dystrophy,
pubmed-meshheading:16920640-RNA-Binding Proteins
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pubmed:articleTitle |
Muscleblind-like protein 1 nuclear sequestration is a molecular pathology marker of DM1 and DM2.
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pubmed:affiliation |
Department of Molecular Biology and Biotechnologies, University of Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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