Linked Life Data

16919057

Source:http://linkedlifedata.com/resource/pubmed/id/16919057

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2006-8-21
pubmed:abstractText
This study investigated nuclear factor-kappa B (NF-kappaB) activity by electrophoresis mobility gel shift assay and IkappaBalpha expression by Western blot analysis in monocytes obtained from serial samples of internal jugular venous blood taken from seven migraine patients without aura during attacks. Inducible nitric oxide synthase (iNOS) expression was also assessed by reverse transcription-polymerase chain reaction. An increase in NF-kappaB activity peaked 2 h after attack onset. This was accompanied by a transient reduction in IkappaBalpha expression. Up-regulation of iNOS was evident at 4 h, maintained at 6 h and reduced at the end of the attack. These findings substantiate the hypothesis of transitory delayed inflammation, as suggested by the animal model, and suggest the possibility of using therapeutic approaches to target NF-kappaB transcription in the treatment of migraine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0333-1024
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1071-9
pubmed:dateRevised
2008-2-11
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
NF-kappaB activity and iNOS expression in monocytes from internal jugular blood of migraine without aura patients during attacks.
pubmed:affiliation
Neurologic Clinic, Department of Medical Specialties and Public Health, University of Perugia, Perugia, Italy. neuro.pg@tiscalinet.it
pubmed:publicationType
Journal Article, Clinical Trial