Source:http://linkedlifedata.com/resource/pubmed/id/16917906
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2006-8-30
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pubmed:abstractText |
Members of the caspase family can be important for apoptosis or inflammation, but the role of caspase-12 (CASP12 or CSP12) is unclear. Although most humans lack a functional caspase-12, the Csp 12-L variant, previously found only among people of African descent, produces a full-length proenzyme and increases the risk of sepsis. In this study, Csp 12-L allele frequency ranged from 3.6% to 60.7% among populations from sub-Saharan Africa and was also present at low frequency among North African, Middle Eastern, and South Asian populations.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1098-1004
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pubmed:author | |
pubmed:copyrightInfo |
Published 2006 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
975
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16917906-Caspase 12,
pubmed-meshheading:16917906-Caspases,
pubmed-meshheading:16917906-Computational Biology,
pubmed-meshheading:16917906-Continental Population Groups,
pubmed-meshheading:16917906-Enzyme Precursors,
pubmed-meshheading:16917906-Gene Frequency,
pubmed-meshheading:16917906-Genetic Predisposition to Disease,
pubmed-meshheading:16917906-Genetics, Population,
pubmed-meshheading:16917906-Humans,
pubmed-meshheading:16917906-Polymorphism, Single Nucleotide,
pubmed-meshheading:16917906-Sepsis
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pubmed:year |
2006
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pubmed:articleTitle |
Population distribution of the functional caspase-12 allele.
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pubmed:affiliation |
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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