Linked Life Data

16917143

Source:http://linkedlifedata.com/resource/pubmed/id/16917143

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-8-18
pubmed:abstractText
Tamoxifen has provided the mainstay of endocrine therapy for more than 20 years. However, the development of the third-generation aromatase inhibitors (AIs), anastrozole, letrozole and exemestane, has provided an alternative strategy for managing hormone-responsive breast cancer in postmenopausal women. The efficacy of the AIs as first- and second-line treatment for advanced disease has been demonstrated in several double-blind, randomised trials and they are now widely accepted in this setting. More recently evidence has emerged supporting the role of aromatase inhibitors in early breast cancer, either as 5 years of initial adjuvant therapy or following 2.5 or 5 years of tamoxifen as part of a switching strategy. Controversy remains over which is the optimal treatment strategy, due to a lack of trials directly comparing initial adjuvant therapy with switching. Nevertheless, the data indicate that the third-generation AIs provide superior recurrence benefits to tamoxifen in the adjuvant setting. In addition, the tolerability profiles of the AIs appear to be more acceptable than tamoxifen, with a reduction in serious adverse events such as endometrial cancer and thromboembolic events associated with the AIs compared with tamoxifen. Ongoing trials aim to clarify the role of the AIs in preoperative treatment and chemoprevention.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0888-6008
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-17
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Aromatase inhibitors: changing the face of endocrine therapy for breast cancer.
pubmed:affiliation
Department of Breast Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. abuzdar@mdanderson.org
pubmed:publicationType
Journal Article, Review