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rdf:type |
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lifeskim:mentions |
umls-concept:C0008565,
umls-concept:C0022322,
umls-concept:C0026131,
umls-concept:C0066646,
umls-concept:C0075804,
umls-concept:C0163557,
umls-concept:C0248572,
umls-concept:C0529813,
umls-concept:C0577559,
umls-concept:C0680730,
umls-concept:C1100440,
umls-concept:C1148554
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pubmed:issue |
4
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pubmed:dateCreated |
2006-8-18
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pubmed:abstractText |
The avermectin and milbemycin families of compounds are derived from naturally occurring yeasts. They have proven to be potent preventatives against a variety of pests such as insects and parasites. Only eprinomectin and moxidectin are currently approved for use on lactating cattle with tolerances in milk of 12 microg/kg for eprinomectin and 40 microg/kg for moxidectin. Detection of misuse or inadvertent contamination in milk requires a sensitive and definitive analytical method. A method has been developed for the determination of 5 avermectins and 1 milbemycin in milk using a simple liquid-liquid extraction and liquid chromatography/tandem mass spectrometry (LC/MS/MS) analysis. Ivermectin (IVR), doramectin (DOR), abamectin (ABA), eprinomectin (EPR), emamectin (EMA), and moxidectin (MOX) were extracted from whole milk by partitioning into acetonitrile with a subsequent solvent exchange into methanol-water. Simultaneous confirmation and quantification were achieved with LC separation, positive electrospray ionization (ESI+), and MS/MS. The limits of detection ranged from 16 pg/g (ppt) for EMA to 1.7 microg/g (ppb) for MOX.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4''-epiacetylamino-4''-deoxyavermect...,
http://linkedlifedata.com/resource/pubmed/chemical/Acetonitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Disaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Insecticides,
http://linkedlifedata.com/resource/pubmed/chemical/Ivermectin,
http://linkedlifedata.com/resource/pubmed/chemical/Macrolides,
http://linkedlifedata.com/resource/pubmed/chemical/Solvents,
http://linkedlifedata.com/resource/pubmed/chemical/Water,
http://linkedlifedata.com/resource/pubmed/chemical/abamectin,
http://linkedlifedata.com/resource/pubmed/chemical/acetonitrile,
http://linkedlifedata.com/resource/pubmed/chemical/doramectin,
http://linkedlifedata.com/resource/pubmed/chemical/emamectin,
http://linkedlifedata.com/resource/pubmed/chemical/milbemycin
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pubmed:status |
MEDLINE
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pubmed:issn |
1060-3271
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1088-94
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16915850-Acetonitriles,
pubmed-meshheading:16915850-Animals,
pubmed-meshheading:16915850-Cattle,
pubmed-meshheading:16915850-Chemistry Techniques, Analytical,
pubmed-meshheading:16915850-Chromatography, Liquid,
pubmed-meshheading:16915850-Disaccharides,
pubmed-meshheading:16915850-Food Analysis,
pubmed-meshheading:16915850-Insecticides,
pubmed-meshheading:16915850-Ivermectin,
pubmed-meshheading:16915850-Macrolides,
pubmed-meshheading:16915850-Milk,
pubmed-meshheading:16915850-Solvents,
pubmed-meshheading:16915850-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:16915850-Water
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pubmed:articleTitle |
Determination of abamectin, doramectin, emamectin, eprinomectin, ivermectin, and moxidectin in milk by liquid chromatography electrospray tandem mass specrometry.
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pubmed:affiliation |
New York State Department of Agriculture and Markets, Food Laboratory Bldg 7, 3rd Floor, State Office Campus, Albany, NY 12235, USA. robert.sheridan@agmkt.state.ny.us
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pubmed:publicationType |
Journal Article
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