Source:http://linkedlifedata.com/resource/pubmed/id/16914834
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2006-8-17
|
| pubmed:abstractText |
PSAPP mice expressing the "Swedish" amyloid precursor protein and M146L presenilin-1 mutations are a well-characterized model for spontaneous amyloid plaque formation. Bacopa monniera has a long history of use in India as an anti-aging and memory-enhancing ethnobotanical therapy. To evaluate the effect of Bacopa monniera extract (BME) on amyloid (Abeta) pathology in PSAPP mice, two doses of BME (40 or 160 mg/kg/day) were administered starting at 2 months of age for either 2 or 8 months. Our present data suggests that BME lowers Abeta 1-40 and 1-42 levels in cortex by as much as 60%, and reverses Y-maze performance and open field hyperlocomotion behavioral changes present in PSAPP mice. The areas encompassed by Congo Red-positive fibrillar amyloid deposits, however, were not altered by BME treatment. The data suggest that BME has potential application in Alzheimer's disease therapeutics.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1387-2877
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
243-51
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| pubmed:meshHeading |
pubmed-meshheading:16914834-Amyloid,
pubmed-meshheading:16914834-Amyloid beta-Protein Precursor,
pubmed-meshheading:16914834-Animals,
pubmed-meshheading:16914834-Bacopa,
pubmed-meshheading:16914834-Behavior, Animal,
pubmed-meshheading:16914834-Body Weight,
pubmed-meshheading:16914834-Brain Chemistry,
pubmed-meshheading:16914834-Cognition,
pubmed-meshheading:16914834-Dose-Response Relationship, Drug,
pubmed-meshheading:16914834-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16914834-Humans,
pubmed-meshheading:16914834-Maze Learning,
pubmed-meshheading:16914834-Mice,
pubmed-meshheading:16914834-Mice, Transgenic,
pubmed-meshheading:16914834-Motor Activity,
pubmed-meshheading:16914834-Neurofibrils,
pubmed-meshheading:16914834-Plant Extracts,
pubmed-meshheading:16914834-Presenilin-1
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Bacopa monniera extract reduces amyloid levels in PSAPP mice.
|
| pubmed:affiliation |
Department of Psychiatry and Behavioral Science, Texas A&M, University System HSC College of Medicine, Temple, TX 76508, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|