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rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2006-8-17
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|
pubmed:abstractText |
Dose-related toxicity of cyclophosphamide may be reduced and therapeutic efficacy may be improved by pharmacokinetic sampling and dose adjustment to achieve a target area under the curve (AUC) for two of its metabolites, hydroxycyclophosphamide (HCY) and carboxyethylphosphoramide mustard (CEPM). To facilitate real-time dose adjustment, we developed open-source code within the statistical software R that incorporates individual data into a population pharmacokinetic model.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Aug
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|
pubmed:issn |
1078-0432
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
12
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4888-98
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16914577-Bayes Theorem,
pubmed-meshheading:16914577-Cyclophosphamide,
pubmed-meshheading:16914577-Dose-Response Relationship, Drug,
pubmed-meshheading:16914577-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:16914577-Humans,
pubmed-meshheading:16914577-Immunosuppressive Agents,
pubmed-meshheading:16914577-Models, Biological,
pubmed-meshheading:16914577-Neoplasms,
pubmed-meshheading:16914577-Nonlinear Dynamics,
pubmed-meshheading:16914577-Phosphoramide Mustards,
pubmed-meshheading:16914577-Software,
pubmed-meshheading:16914577-Transplantation Conditioning
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pubmed:year |
2006
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|
pubmed:articleTitle |
Real-time dose adjustment of cyclophosphamide in a preparative regimen for hematopoietic cell transplant: a Bayesian pharmacokinetic approach.
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pubmed:affiliation |
Departments of Pharmacy, University of Washington, Seattle, Washington, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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