Linked Life Data

16914153

Source:http://linkedlifedata.com/resource/pubmed/id/16914153

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-9-5
pubmed:abstractText
This review presents supporting evidence that early disruptions in mother-infant relationship in primates, including infant maltreatment, are important risk factors for the development of psychopathology and pathophysiology during childhood and adolescence. Current research in this field is trying to identify important aspects of early adverse experiences such as the timing, frequency, duration, "perceived" intensity of the stressful or traumatic events, the role of social support (e.g., nurturing caregiver) in buffering the deleterious outcomes of early adversity, as well as the role of sex and genetic factors on individual variability in vulnerability. The use of nonhuman primate models of early adverse caregiving is helping to put the pieces of the puzzle together to fully understand the causes and consequences of similar experiences in humans. These models are essential to characterize the time course of biobehavioral alterations throughout development, using prospective, longitudinal studies performed under controlled experimental conditions and using invasive approaches that are unrealistic and unethical when studying human populations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0018-506X
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
623-31
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
The impact of early adverse care on HPA axis development: nonhuman primate models.
pubmed:affiliation
Department of Psychiatry and Behavioral Science, Emory University School of Medicine, Atlanta, GA 30322, USA. sanchez@rmy.emory.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural