| pubmed-article:1691379 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1691379 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:1691379 | lifeskim:mentions | umls-concept:C0025474 | lld:lifeskim |
| pubmed-article:1691379 | lifeskim:mentions | umls-concept:C0032912 | lld:lifeskim |
| pubmed-article:1691379 | lifeskim:mentions | umls-concept:C0237753 | lld:lifeskim |
| pubmed-article:1691379 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:1691379 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:1691379 | lifeskim:mentions | umls-concept:C0242546 | lld:lifeskim |
| pubmed-article:1691379 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1691379 | pubmed:dateCreated | 1990-5-24 | lld:pubmed |
| pubmed-article:1691379 | pubmed:abstractText | Binding of the alpha-adrenergic antagonists [3H]prazosin and [3H]rauwolscine to well-characterized subcellular membrane fractions isolated from dog mesenteric arteries and veins was studied. Binding of both ligands was saturable with Kd values of 0.5 +/- 0.1 nM for [3H]prazosin and 5.85 +/- 0.85 nM for [3H]rauwolscine in arteries, and 0.87 +/- 0.4 nM for [3H]prazosin and 6.6 +/- 1.5 nM for [3H]rauwolscine in veins. In veins, the maximum number of binding sites for [3H]rauwolscine was higher than that for [3H]prazosin, whereas in arteries the maximum number of binding sites for each ligand was similar. In microsomes from dog aorta, the maximum number of bindings sites for [3H]prazosin was higher than that for [3H]rauwolscine. Neuronal membrane contamination in these studies was minimized by dissection procedures and evaluated by the comparison of [3H]saxitoxin binding in various preparations. Only mesenteric veins responded functionally to agonists acting on alpha 2 adrenoceptors. This study thus identified two distinct populations of [3H]prazosin and [3H]rauwolscine binding sites in the plasma membranes of dog mesenteric vessels and suggests that a much higher density of alpha 2-compared to alpha 1-adrenoceptor binding sites is required for a contractile response. | lld:pubmed |
| pubmed-article:1691379 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1691379 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691379 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1691379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1691379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1691379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1691379 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1691379 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1691379 | pubmed:issn | 0160-2446 | lld:pubmed |
| pubmed-article:1691379 | pubmed:author | pubmed-author:DanielE EEE | lld:pubmed |
| pubmed-article:1691379 | pubmed:author | pubmed-author:AhmadSS | lld:pubmed |
| pubmed-article:1691379 | pubmed:author | pubmed-author:JannRR | lld:pubmed |
| pubmed-article:1691379 | pubmed:author | pubmed-author:ShiA GAG | lld:pubmed |
| pubmed-article:1691379 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1691379 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:1691379 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1691379 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1691379 | pubmed:pagination | 515-26 | lld:pubmed |
| pubmed-article:1691379 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1691379 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1691379 | pubmed:articleTitle | Alpha-adrenoceptors in dog mesenteric vessels--subcellular distribution and number of [3H]prazosin and [3H]rauwolscine binding sites. | lld:pubmed |
| pubmed-article:1691379 | pubmed:affiliation | Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. | lld:pubmed |
| pubmed-article:1691379 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1691379 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1691379 | lld:pubmed |
