Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2006-8-16
pubmed:abstractText
Apoptosis is critical for the development and maintenance of the immune system. The proapoptotic Bcl-2 family member Bim is important for normal immune system homeostasis. Although previous experiments have shown that Bim is critical for the apoptosis of antigen-specific CD8(+) T cells during acute viral infection, the role of Bim during chronic viral infection is unclear. Using lymphocytic choriomeningitis virus clone 13 infection of mice, we demonstrate a role for Bim in CD8(+) T-cell apoptosis during chronic viral infection. Enumeration of antigen-specific CD8(+) T cells by major histocompatibility complex class I tetramer staining revealed that CD8(+) D(b)NP396-404(+) T cells, which undergo extensive deletion in wild-type mice, exhibited almost no decrease in Bim mutant mice. This contrasts with CD8(+) D(b)GP33-41(+) and CD8(+) D(b)GP276-286(+) T cells that underwent similar decreases in numbers in both Bim mutant and wild-type mice. Increased numbers of CD8(+) D(b)NP396-404(+) T cells in Bim mutant mice were due to lack of apoptosis and could not be explained by altered proliferation, differential homing to tissues, or increased help from CD4(+) T cells. When viral titers were examined, high levels were initially observed in both groups, but in Bim mutant mice, clearance from the spleen and sera was slightly accelerated. These experiments demonstrate the critical role of Bim during chronic viral infection to down-regulate CD8(+) T-cell responses and have implications for designing strategies for optimizing immunotherapies during situations where antigen persists, such as chronic infection, autoimmune syndromes, and cancer.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-10198631, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-10415021, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-10558996, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-10576740, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-10605013, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-10671226, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-10671227, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-10754284, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-11323695, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-11581375, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-11709185, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-11752172, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-11859372, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-11884558, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-11994430, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-12055624, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-12086884, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-12121658, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-12185265, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-12496434, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-12663797, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-12690201, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-12690202, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-14623954, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-14625547, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-15047807, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-15136728, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-15232608, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-15272399, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-15300249, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-15363492, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-15557151, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-15750290, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-15885625, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-16181084, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-16188973, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-16219166, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-3336942, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-6332167, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-7604887, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-8207839, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-8892953, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-9430630, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-9491998, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-9491999, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-9516110, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-9529152, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-9731710, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-9782116, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912311-9858507
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8627-38
pubmed:dateRevised
2010-12-3
pubmed:meshHeading
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