| pubmed-article:16912280 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16912280 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:16912280 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:16912280 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:16912280 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:16912280 | lifeskim:mentions | umls-concept:C0243041 | lld:lifeskim |
| pubmed-article:16912280 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:16912280 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:16912280 | pubmed:dateCreated | 2006-8-16 | lld:pubmed |
| pubmed-article:16912280 | pubmed:abstractText | The sigma(28) protein is a member of the bacterial sigma(70)-family of transcription factors that directs RNA polymerase to flagellar late (class 3) promoters. The sigma(28) protein is regulated in response to flagellar assembly by the anti-sigma(28) factor FlgM. FlgM inhibits sigma(28)-dependent transcription of genes whose products are needed late in assembly until the flagellar basal motor structure, the hook-basal body (HBB), is constructed. A second function for the sigma(28) transcription factor has been discovered: sigma(28) facilitates the secretion of FlgM through the HBB, acting as the FlgM Type III secretion chaperone. Transcription-specific mutants in sigma(28) were isolated that remained competent for FlgM-facilitated secretion separating the transcription and secretion-facilitation activities of sigma (28). Conversely, we also describe the isolation of mutants in sigma(28) that are specific for FlgM-facilitated secretion. The data demonstrate that sigma(28) is the Type III secretion chaperone for its own anti-sigma factor FlgM. Thus, a novel role for a sigma(70)-family transcription factor is described. | lld:pubmed |
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| pubmed-article:16912280 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16912280 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16912280 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16912280 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16912280 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:16912280 | pubmed:author | pubmed-author:HughesKelly... | lld:pubmed |
| pubmed-article:16912280 | pubmed:author | pubmed-author:AldridgeChris... | lld:pubmed |
| pubmed-article:16912280 | pubmed:author | pubmed-author:AldridgePhill... | lld:pubmed |
| pubmed-article:16912280 | pubmed:author | pubmed-author:KarlinseyJoyc... | lld:pubmed |
| pubmed-article:16912280 | pubmed:author | pubmed-author:YagasakiJinJ | lld:pubmed |
| pubmed-article:16912280 | pubmed:author | pubmed-author:BirchallChris... | lld:pubmed |
| pubmed-article:16912280 | pubmed:author | pubmed-author:ThompsonDanie... | lld:pubmed |
| pubmed-article:16912280 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16912280 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16912280 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:16912280 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16912280 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16912280 | pubmed:pagination | 2315-26 | lld:pubmed |
| pubmed-article:16912280 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16912280 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16912280 | pubmed:articleTitle | The flagellar-specific transcription factor, sigma28, is the Type III secretion chaperone for the flagellar-specific anti-sigma28 factor FlgM. | lld:pubmed |
| pubmed-article:16912280 | pubmed:affiliation | Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. p.d.aldridge@ncl.ac.uk | lld:pubmed |
| pubmed-article:16912280 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16912280 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16912280 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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