|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
2006-8-16
|
|
pubmed:abstractText |
The sigma(28) protein is a member of the bacterial sigma(70)-family of transcription factors that directs RNA polymerase to flagellar late (class 3) promoters. The sigma(28) protein is regulated in response to flagellar assembly by the anti-sigma(28) factor FlgM. FlgM inhibits sigma(28)-dependent transcription of genes whose products are needed late in assembly until the flagellar basal motor structure, the hook-basal body (HBB), is constructed. A second function for the sigma(28) transcription factor has been discovered: sigma(28) facilitates the secretion of FlgM through the HBB, acting as the FlgM Type III secretion chaperone. Transcription-specific mutants in sigma(28) were isolated that remained competent for FlgM-facilitated secretion separating the transcription and secretion-facilitation activities of sigma (28). Conversely, we also describe the isolation of mutants in sigma(28) that are specific for FlgM-facilitated secretion. The data demonstrate that sigma(28) is the Type III secretion chaperone for its own anti-sigma factor FlgM. Thus, a novel role for a sigma(70)-family transcription factor is described.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-10231493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-10320579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-10564473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-10572114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-10785634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-10829079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-10966110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-10972838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-11104815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-11168592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-11237608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-11296219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-11327763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-11677609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-11934612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-12615213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-12620614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-12775694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-12940991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-14506477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-1453955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-14756788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-1482109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-15001708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-15068809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-15916611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-16139196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-16172384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-16208377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-16352826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-16507363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-16513753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-1655712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-16629666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-2404955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-4593496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-7007341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-7961507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-8235660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-9095196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-9765212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912280-9988479
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0890-9369
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2315-26
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
The flagellar-specific transcription factor, sigma28, is the Type III secretion chaperone for the flagellar-specific anti-sigma28 factor FlgM.
|
|
pubmed:affiliation |
Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. p.d.aldridge@ncl.ac.uk
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
