Linked Life Data

16910834

Source:http://linkedlifedata.com/resource/pubmed/id/16910834

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2006-8-16
pubmed:abstractText
CD4+ T cell counts and CD4+:CD8+ T cell ratios represent key determinants of HIV disease progression and infectivity. However, the relationship between the HIV-1-specific cytotoxic T lymphocyte (CTL) response and these determinants has not been elucidated for all HIV-1B and HIV-1C proteins. In the present study, virusspecific T cell responses to HIV-1B and HIV-1C proteins were analyzed with interferon gamma (IFN-gamma) enzyme- linked immunospot (ELISpot) assays using synthetic overlapping peptides corresponding to naturally occurring HIV-1B and HIV-1C consensus sequences. For Gag/Gag p24/Gag p17, a correlation between T cell responses and CD4+ T cell count in HIV-1 clade B and clade C was seen: elevated T cell response resulted in higher CD4+ T cell production. A statistically significant correlation between the Pol-specific T cell response and CD4+ T cell counts was also found in HIV-1 subtype C. For all HIV-1B and HIV-1C proteins, a correlation between the HIV-1-specific T cell response and CD4+:CD8+ T cell ratios was found for Tat and Pol proteins. CD4+ T cell counts in patients with Tat and/or Rev T cell response were higher than in patients without Tat and/or Rev T cell response. We suggest that this correlation within HIV-1B and HIV-1C Gag p24/Gag p17 responses makes the Gag p24/Gag p17 region a potential vaccine candidate and that HIV-1-specific CTL epitopes toward Pol are important in controlling HIV-1 infection; we emphasize that future vaccination strategies should include these early antigens, Tat and Rev.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0889-2229
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
780-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16910834-Adolescent, pubmed-meshheading:16910834-Adult, pubmed-meshheading:16910834-CD4 Lymphocyte Count, pubmed-meshheading:16910834-CD4-CD8 Ratio, pubmed-meshheading:16910834-China, pubmed-meshheading:16910834-Female, pubmed-meshheading:16910834-Gene Products, gag, pubmed-meshheading:16910834-HIV Antigens, pubmed-meshheading:16910834-HIV Core Protein p24, pubmed-meshheading:16910834-HIV Infections, pubmed-meshheading:16910834-HIV-1, pubmed-meshheading:16910834-Humans, pubmed-meshheading:16910834-Male, pubmed-meshheading:16910834-Middle Aged, pubmed-meshheading:16910834-Species Specificity, pubmed-meshheading:16910834-T-Lymphocytes, Cytotoxic, pubmed-meshheading:16910834-Viral Load, pubmed-meshheading:16910834-Viral Proteins, pubmed-meshheading:16910834-gag Gene Products, Human Immunodeficiency Virus
pubmed:year
2006
pubmed:articleTitle
Association between HIV Type 1-specific T cell responses and CD4+ T cell counts or CD4+:CD8+ T cell ratios in HIV Type 1 subtype B infection in China.
pubmed:affiliation
Department of Infectious Diseases, Tangdu Hospital Affiliated to the Fourth Military Medical University, Xi'an 710038, Peoples Republic of China.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural