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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1990-5-18
|
pubmed:abstractText |
The flare and weal reactions to intradermal injections of histamine and the peptide substance P were measured in a group of patients with atopic dermatitis and compared to reactions in a non-atopic control group. There was no significant difference in the flare areas between the controls and atopics with either reagent. The weal volumes after injection of substance P and histamine were significantly larger in the atopic group. As substance P causes mast cell histamine release, the increased weal volumes produced by substance P in the atopics may be entirely due to the exaggerated atopic weal reaction to histamine.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0007-0963
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
122
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
343-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1691013-Adult,
pubmed-meshheading:1691013-Dermatitis, Atopic,
pubmed-meshheading:1691013-Dose-Response Relationship, Drug,
pubmed-meshheading:1691013-Histamine,
pubmed-meshheading:1691013-Humans,
pubmed-meshheading:1691013-Mast Cells,
pubmed-meshheading:1691013-Skin,
pubmed-meshheading:1691013-Substance P,
pubmed-meshheading:1691013-Time Factors
|
pubmed:year |
1990
|
pubmed:articleTitle |
Cutaneous reactions to substance P and histamine in atopic dermatitis.
|
pubmed:affiliation |
Skin Laboratory, St Helier Hospital, Carshalton, Surrey, U.K.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|