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pubmed:abstractText |
To present a novel strategy for mapping quantitative trait loci (QTL), using human metapopulations. The strategy is based on the expectation that in geographic clusters of small and distinct human isolates, a combination of founder effect and genetic drift can dramatically increase population frequency of rare QTL variants with large effect. In such cases, the distribution of QT measurements in an (affected) isolate is expected to deviate from that observed in neighboring isolates.
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pubmed:affiliation |
Department of Public Health Sciences, Faculty of Medicine, University of Edinburgh, Edinburgh, Scotland, UK. irudan@mef.hr
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