|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0005437,
umls-concept:C0032105,
umls-concept:C0080103,
umls-concept:C0086287,
umls-concept:C0086418,
umls-concept:C0086582,
umls-concept:C0441833,
umls-concept:C0441889,
umls-concept:C0537026,
umls-concept:C0599755,
umls-concept:C1710263,
umls-concept:C1880371,
umls-concept:C1882417,
umls-concept:C1999270
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pubmed:issue |
10
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|
pubmed:dateCreated |
2006-10-5
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pubmed:abstractText |
The objective of this study was to investigate the prevalence of different polymorphisms and haplotypes associated with individual variations in pharmacokinetics and drug toxicity in the uridine-diphosphate glucuronosyl transferase (UGT) 1A gene in a Swedish cohort (248 healthy volunteers) and in 14 different ethnic groups. We also estimated UGT1A genotype-dependent glucuronidation efficiency using the endogenous substrate bilirubin as an indicator.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0031-6970
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
829-37
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pubmed:dateRevised |
2009-11-3
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pubmed:meshHeading |
pubmed-meshheading:16909274-Adult,
pubmed-meshheading:16909274-African Continental Ancestry Group,
pubmed-meshheading:16909274-Alleles,
pubmed-meshheading:16909274-Asian Continental Ancestry Group,
pubmed-meshheading:16909274-Base Sequence,
pubmed-meshheading:16909274-Bilirubin,
pubmed-meshheading:16909274-Cohort Studies,
pubmed-meshheading:16909274-European Continental Ancestry Group,
pubmed-meshheading:16909274-Female,
pubmed-meshheading:16909274-Gene Frequency,
pubmed-meshheading:16909274-Genetic Variation,
pubmed-meshheading:16909274-Genotype,
pubmed-meshheading:16909274-Glucuronides,
pubmed-meshheading:16909274-Glucuronosyltransferase,
pubmed-meshheading:16909274-Haplotypes,
pubmed-meshheading:16909274-Humans,
pubmed-meshheading:16909274-Isoenzymes,
pubmed-meshheading:16909274-Linkage Disequilibrium,
pubmed-meshheading:16909274-Male,
pubmed-meshheading:16909274-Phylogeny,
pubmed-meshheading:16909274-Polymorphism, Genetic,
pubmed-meshheading:16909274-Sequence Analysis, DNA,
pubmed-meshheading:16909274-Sex Factors,
pubmed-meshheading:16909274-Sweden
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pubmed:year |
2006
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pubmed:articleTitle |
UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females.
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pubmed:affiliation |
Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden.
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pubmed:publicationType |
Journal Article
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