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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-8-30
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pubmed:abstractText |
Angiotensin II (Ang II) has been reported to contribute to the pathogenesis of various human diseases including atherosclerosis, and inhibition of Ang II activity has been shown to reduce the morbidity and mortality of cardiovascular diseases. We have previously demonstrated that vascular cell senescence contributes to the pathogenesis of atherosclerosis; however, the effects of Ang II on vascular cell senescence have not been examined.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:KanekoShuichiS,
pubmed-author:KatsunoTaroT,
pubmed-author:KomuroIsseiI,
pubmed-author:KuniedaTakeshigeT,
pubmed-author:MinaminoTohruT,
pubmed-author:MiyauchiHideyukiH,
pubmed-author:NagaiToshioT,
pubmed-author:NishiJun-IchiroJ,
pubmed-author:OkadaShoS,
pubmed-author:OrimoMasayukiM,
pubmed-author:OyamaTomomiT,
pubmed-author:TakamuraMasayukiM,
pubmed-author:TatenoKaoruK
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
953-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16908765-Aging, Premature,
pubmed-meshheading:16908765-Angiotensin II,
pubmed-meshheading:16908765-Animals,
pubmed-meshheading:16908765-Aorta,
pubmed-meshheading:16908765-Apolipoproteins E,
pubmed-meshheading:16908765-Atherosclerosis,
pubmed-meshheading:16908765-Blood Pressure,
pubmed-meshheading:16908765-Cells, Cultured,
pubmed-meshheading:16908765-Disease Models, Animal,
pubmed-meshheading:16908765-Genes, Reporter,
pubmed-meshheading:16908765-Mice,
pubmed-meshheading:16908765-Mice, Inbred C57BL,
pubmed-meshheading:16908765-Mice, Knockout,
pubmed-meshheading:16908765-Muscle, Smooth, Vascular,
pubmed-meshheading:16908765-Transfection
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pubmed:year |
2006
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pubmed:articleTitle |
Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway.
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pubmed:affiliation |
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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