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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-9-6
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pubmed:abstractText |
IFN-gamma is an important Th1 proinflammatory cytokine and has a paradoxical effect on EAE in which disease susceptibility is unexpectedly heightened in IFN-gamma-deficient mice. In this study, we provide what we believe is new evidence indicating that IFN-gamma is critically required for the conversion of CD4+ CD25- T cells to CD4+ Tregs during EAE. In our study, the added severity of EAE in IFN-gamma knockout mice was directly associated with altered encephalitogenic T cell responses, which correlated with reduced frequency and function of CD4+ CD25+ Foxp3+ Tregs when compared with those of WT mice. It was demonstrated in both human and mouse systems that in vitro IFN-gamma treatment of CD4+ CD25- T cells led to conversion of CD4+ Tregs as characterized by increased expression of Foxp3 and enhanced regulatory function. Mouse CD4+ CD25- T cells, when treated in vitro with IFN-gamma, acquired marked regulatory properties as evidenced by suppression of EAE by adoptive transfer. These findings have important implications for the understanding of the complex role of IFN-gamma in both induction and self regulation of inflammatory processes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-10190695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-10553050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-10595504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-10673376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-10679118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-10837065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-10880533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-11102772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-11138001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-11483607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-11722629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-12034883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-12522256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-12612578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-12612581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-12626591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-14597106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-14597756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-14597769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-14644034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-14676299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-14699080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-15067033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-15207505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-15743488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-15905186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-7590816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-7880387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-8283058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-8598493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-8766573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-8871615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-9190954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-9288735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16906223-9892605
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin-Associated Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/myelin oligodendrocyte glycoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2434-41
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16906223-Amino Acid Sequence,
pubmed-meshheading:16906223-Animals,
pubmed-meshheading:16906223-Antigens, CD4,
pubmed-meshheading:16906223-Brain,
pubmed-meshheading:16906223-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:16906223-Forkhead Transcription Factors,
pubmed-meshheading:16906223-Interferon-gamma,
pubmed-meshheading:16906223-Mice,
pubmed-meshheading:16906223-Mice, Inbred C57BL,
pubmed-meshheading:16906223-Mice, Knockout,
pubmed-meshheading:16906223-Molecular Sequence Data,
pubmed-meshheading:16906223-Myelin Proteins,
pubmed-meshheading:16906223-Myelin-Associated Glycoprotein,
pubmed-meshheading:16906223-Peptide Fragments,
pubmed-meshheading:16906223-Polymerase Chain Reaction,
pubmed-meshheading:16906223-Receptors, Interleukin-2,
pubmed-meshheading:16906223-Spinal Cord,
pubmed-meshheading:16906223-T-Lymphocytes
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pubmed:year |
2006
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pubmed:articleTitle |
Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs.
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pubmed:affiliation |
Joint Immunology Laboratory of Institute of Health Sciences, Shanghai JiaoTong University School of Medicine, and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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