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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-8-14
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pubmed:abstractText |
Methotrexate (MTX) represents the antirheumatic drug mainly used in rheumatoid arthritis (RA). HLA-G antigens are inducible nonclassical major histocompatibility complex class Ib molecules important for maintaining anti-inflammatory conditions. The HLA-G gene is characterized by a deletion/insertion polymorphism of 14 bp that controls specific mRNA stability and protein levels. It has been reported that MTX therapy mediates an increase of interleukin-10-producing cells. This cytokine up-regulates HLA-G expression. For this, we tested the hypothesis of an MTX-mediated HLA-G production and the possible relationship with the HLA-G 14-bp polymorphism.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1744-6872
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
615-23
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16906016-Aged,
pubmed-meshheading:16906016-Antigens, CD14,
pubmed-meshheading:16906016-Arthritis, Rheumatoid,
pubmed-meshheading:16906016-Case-Control Studies,
pubmed-meshheading:16906016-Female,
pubmed-meshheading:16906016-Gene Frequency,
pubmed-meshheading:16906016-Genetic Linkage,
pubmed-meshheading:16906016-Genotype,
pubmed-meshheading:16906016-HLA Antigens,
pubmed-meshheading:16906016-HLA-G Antigens,
pubmed-meshheading:16906016-Histocompatibility Antigens Class I,
pubmed-meshheading:16906016-Humans,
pubmed-meshheading:16906016-Interleukin-10,
pubmed-meshheading:16906016-Leukocytes,
pubmed-meshheading:16906016-Male,
pubmed-meshheading:16906016-Methotrexate,
pubmed-meshheading:16906016-Middle Aged,
pubmed-meshheading:16906016-Polymorphism, Genetic,
pubmed-meshheading:16906016-Retrospective Studies,
pubmed-meshheading:16906016-Statistics as Topic,
pubmed-meshheading:16906016-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
HLA-G 14-bp polymorphism regulates the methotrexate response in rheumatoid arthritis.
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pubmed:affiliation |
Section of Medical Genetics, Department of Experimental and Diagnostic Medicine University of Ferrara, Ferrara, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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