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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-5-4
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pubmed:abstractText |
The ability of bleomycin to cleave DNA fragments containing (TA)n and (GA)n/(CT)n inserts has been investigated. Bleomycin cuts efficiently after AT and GA though not at TA, AG and CT or TC. In the presence of ligands which modify DNA structure new cleavage products appear. It seems that the ability of bleomycin to discriminate between various sequences arises from their structural characteristics rather than merely from base-specific hydrogen bond contacts.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Feb
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pubmed:issn |
0266-9536
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
99-104
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pubmed:dateRevised |
2010-8-25
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pubmed:meshHeading |
pubmed-meshheading:1690547-Base Composition,
pubmed-meshheading:1690547-Base Sequence,
pubmed-meshheading:1690547-Bleomycin,
pubmed-meshheading:1690547-DNA,
pubmed-meshheading:1690547-Dactinomycin,
pubmed-meshheading:1690547-Drug Interactions,
pubmed-meshheading:1690547-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:1690547-Ligands,
pubmed-meshheading:1690547-Plasmids,
pubmed-meshheading:1690547-Structure-Activity Relationship
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|
pubmed:year |
1990
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|
pubmed:articleTitle |
DNA sequence recognition by bleomycin.
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|
pubmed:affiliation |
Department of Physiology & Pharmacology, University of Southampton, UK.
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pubmed:publicationType |
Journal Article,
In Vitro
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