16905319

Source:http://linkedlifedata.com/resource/pubmed/id/16905319

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0032699, umls-concept:C0243076, umls-concept:C0298537, umls-concept:C1058551
pubmed:issue	20
pubmed:dateCreated	2006-9-11
pubmed:abstractText	Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear, http://linkedlifedata.com/resource/pubmed/chemical/Sesterterpenes, http://linkedlifedata.com/resource/pubmed/chemical/Terpenes, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/farnesoid X-activated receptor
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0960-894X
pubmed:author	pubmed-author:ChinJungwookJ, pubmed-author:ChoiHyukjaeH, pubmed-author:HamJungyeobJ, pubmed-author:KangHeonjoongH, pubmed-author:KimHeeyoungH, pubmed-author:KimYoungshinY, pubmed-author:KoHyunsilH, pubmed-author:NamSang-JipSJ, pubmed-author:ShinKyoungjinK, pubmed-author:ShinMiheeM
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	16
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	5398-402
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:16905319-Animals, pubmed-meshheading:16905319-Cell Line, pubmed-meshheading:16905319-Cell Proliferation, pubmed-meshheading:16905319-Cercopithecus aethiops, pubmed-meshheading:16905319-DNA-Binding Proteins, pubmed-meshheading:16905319-Magnetic Resonance Spectroscopy, pubmed-meshheading:16905319-Molecular Conformation, pubmed-meshheading:16905319-Porifera, pubmed-meshheading:16905319-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:16905319-Reference Standards, pubmed-meshheading:16905319-Sesterterpenes, pubmed-meshheading:16905319-Stereoisomerism, pubmed-meshheading:16905319-Structure-Activity Relationship, pubmed-meshheading:16905319-Terpenes, pubmed-meshheading:16905319-Transcription Factors, pubmed-meshheading:16905319-Transcriptional Activation, pubmed-meshheading:16905319-Transfection
pubmed:year	2006
pubmed:articleTitle	Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.
pubmed:affiliation	Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Republic of Korea.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't