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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-8-14
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pubmed:abstractText |
Pancreatic cancer is highly resistant to radiation and chemotherapy, and its resistance reflects the enhancement of apoptosis inhibitory genes, including Bcl-2 family. Antennapedia (pAnt) is capable of almost 100% internalization into cells through the lipid bilayer without any cytotoxic effect. The aim of this study was to examine the effects of the Bcl-XL antisense oligonucleotide for radiosensitivity of in vitro and in vivo pancreatic cancer using oligonucleotide conjugated with antennapedia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
pubmed-author:DoiRyuichiroR,
pubmed-author:FujimotoKojiK,
pubmed-author:HosotaniRyoR,
pubmed-author:ItoDaisukeD,
pubmed-author:KamiKazuhiroK,
pubmed-author:KoizumiMasayukiM,
pubmed-author:MasuiToshihikoT,
pubmed-author:MiyamotoYoshiharuY,
pubmed-author:MoriTomohikoT,
pubmed-author:NakajimaSanaeS,
pubmed-author:ToyodaEijiE
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pubmed:issnType |
Print
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
149-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16904964-Animals,
pubmed-meshheading:16904964-Antennapedia Homeodomain Protein,
pubmed-meshheading:16904964-Apoptosis,
pubmed-meshheading:16904964-Cell Culture Techniques,
pubmed-meshheading:16904964-Cell Line, Tumor,
pubmed-meshheading:16904964-Disease Models, Animal,
pubmed-meshheading:16904964-Male,
pubmed-meshheading:16904964-Mice,
pubmed-meshheading:16904964-Mice, Inbred BALB C,
pubmed-meshheading:16904964-Neoplasm Transplantation,
pubmed-meshheading:16904964-Oligonucleotides, Antisense,
pubmed-meshheading:16904964-Pancreatic Neoplasms,
pubmed-meshheading:16904964-bcl-X Protein
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pubmed:year |
2006
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pubmed:articleTitle |
Bcl-XL antisense oligonucleotides coupled with antennapedia enhances radiation-induced apoptosis in pancreatic cancer.
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pubmed:affiliation |
Department of Surgery and Surgical Basic Science, Kyoto University, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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