Linked Life Data

1690366

Source:http://linkedlifedata.com/resource/pubmed/id/1690366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1990-4-25
pubmed:abstractText
The interaction between intrathecally (i.t.) applied galanin (GAL) and morphine was examined in electrophysiological and behavioural experiments. The physiological experiments were performed on decerebrate, spinalized, unanesthetized rats where the effects of i.t. GAL and morphine on the hamstring flexor reflex were studied. In the behavioural experiments sensitivity to noxious thermal stimulation was assessed on the hot plate test in rats injected with GAL and morphine via chronically implanted i.t. catheters. GAL at 100 ng in 10 microliters, which by itself has no depressive effect, potentiated the depressive effect of morphine on the flexor reflex. In the behavioral study the same dose of GAL potentiated the antinociceptive effect of morphine on the hot plate test without having an analgesic effect by itself. It is suggested that GAL may enhance the analgesic effect of opiates in the spinal cord.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-21
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Intrathecal galanin potentiates the spinal analgesic effect of morphine: electrophysiological and behavioural studies.
pubmed:affiliation
Department of Clinical Neurophysiology and Physiology, Karolinska Institute, Huddinge, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't