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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5788
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pubmed:dateCreated |
2006-8-11
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pubmed:databankReference |
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pubmed:abstractText |
Transient infection of eukaryotic cells with commensal and extraintestinal pathogenic Escherichia coli of phylogenetic group B2 blocks mitosis and induces megalocytosis. This trait is linked to a widely spread genomic island that encodes giant modular nonribosomal peptide and polyketide synthases. Contact with E. coli expressing this gene cluster causes DNA double-strand breaks and activation of the DNA damage checkpoint pathway, leading to cell cycle arrest and eventually to cell death. Discovery of hybrid peptide-polyketide genotoxins in E. coli will change our view on pathogenesis and commensalism and open new biotechnological applications.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/H2AFX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Mutagens,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Polyketide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ataxia telangiectasia mutated...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
313
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
848-51
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:16902142-Animals,
pubmed-meshheading:16902142-Cell Cycle,
pubmed-meshheading:16902142-Cell Cycle Proteins,
pubmed-meshheading:16902142-Cell Death,
pubmed-meshheading:16902142-Cell Line,
pubmed-meshheading:16902142-Cell Nucleus,
pubmed-meshheading:16902142-Cytotoxins,
pubmed-meshheading:16902142-DNA,
pubmed-meshheading:16902142-DNA Damage,
pubmed-meshheading:16902142-DNA-Binding Proteins,
pubmed-meshheading:16902142-Escherichia coli,
pubmed-meshheading:16902142-G2 Phase,
pubmed-meshheading:16902142-Genomic Islands,
pubmed-meshheading:16902142-HeLa Cells,
pubmed-meshheading:16902142-Histones,
pubmed-meshheading:16902142-Humans,
pubmed-meshheading:16902142-Intestinal Mucosa,
pubmed-meshheading:16902142-Molecular Sequence Data,
pubmed-meshheading:16902142-Mutagenesis,
pubmed-meshheading:16902142-Mutagens,
pubmed-meshheading:16902142-Peptides,
pubmed-meshheading:16902142-Phosphorylation,
pubmed-meshheading:16902142-Polyketide Synthases,
pubmed-meshheading:16902142-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16902142-Rats,
pubmed-meshheading:16902142-Signal Transduction,
pubmed-meshheading:16902142-Tumor Suppressor Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Escherichia coli induces DNA double-strand breaks in eukaryotic cells.
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pubmed:affiliation |
INRA, UMR1225, Ecole Nationale Vétérinaire de Toulouse, Toulouse F-31076, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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