Linked Life Data

1690142

Source:http://linkedlifedata.com/resource/pubmed/id/1690142

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-4-17
pubmed:abstractText
We have developed a retinal microvessel culture system which permits study of the initial events of endothelial cell activation and migration during the angiogenic response. Enzyme digest experiments indicate that Type IV collagen is the major basement membrane component regulating migration and growth of endothelial cells. Following removal of basement membrane collagen, further cell migration and proliferation require a suitable substrate. Laminin, fibronectin and fibrin(ogen) provide excellent substrates for endothelial cell outgrowths while Type I collagen, even if prepared as a three-dimensional gel, or Type IV collagen fails to promote typical cell growth. In contrast to fibrin and fibronectin, plasmin was a poor substrate for cell outgrowth and it is suggested that cell-associated protease activity may exert a regulatory role over endothelial cell-matrix interactions during cell migration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Factors affecting the migration and growth of endothelial cells from microvessels of bovine retina.
pubmed:affiliation
Department of Ophthalmology, University of Aberdeen, Medical School, Foresterhill, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't