Source:http://linkedlifedata.com/resource/pubmed/id/16901028
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2006-8-11
|
| pubmed:abstractText |
Bisphosphonates are effective in the prevention and treatment of bone disease in multiple myeloma (MM). Osteonecrosis of the jaw is Increasingly recognized as a serious complication of long-term bisphosphonate therapy. Issues such as the choice of bisphosphonate and duration of therapy have become the subject of intense debate given patient safety concerns. We reviewed available data concerning the use of bisphosphonates in MM. Guidelines for the use of bisphosphonates in MM were developed by a multidisciplinary panel consisting of hematologists, dental specialists, and nurses specializing in the treatment of MM. We conclude that intravenous pamidronate and intravenous zoledronic acid are equally effective and superior to placebo in reducing skeletal complications. Pamidronate is favored over zoledronic acid until more data are available on the risk of complications (osteonecrosis of the jaw). We recommend discontinuing bisphosphonates after 2 years of therapy for patients who achieve complete response and/or plateau phase. For patients whose disease is active, who have not achieved a response, or who have threatening bone disease beyond 2 years, therapy can be decreased to every 3 months. These guidelines were developed in the Interest of patient safety and will be reexamined as new data emerge regarding risks and benefits.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Density Conservation Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Diphosphonates,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/pamidronate,
http://linkedlifedata.com/resource/pubmed/chemical/zoledronic acid
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0025-6196
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| pubmed:author |
pubmed-author:BergsagelP LiefPL,
pubmed-author:CarrAlan BAB,
pubmed-author:DaltonRobert JRJ,
pubmed-author:DingliDavidD,
pubmed-author:DispenzieriAngelaA,
pubmed-author:FonsecaRafaelR,
pubmed-author:GertzMorie AMA,
pubmed-author:GollbachKimberly LKL,
pubmed-author:GreippPhilip RPR,
pubmed-author:HaymanSuzanne RSR,
pubmed-author:KademaniDeepakD,
pubmed-author:KellerEugene EEE,
pubmed-author:KumarShajiS,
pubmed-author:KyleRobert ARA,
pubmed-author:LacyMartha QMQ,
pubmed-author:LustJohn AJA,
pubmed-author:RajkumarS VincentSV,
pubmed-author:ReederCraig BCB,
pubmed-author:RoyVivekV,
pubmed-author:RussellStephen JSJ,
pubmed-author:StewartA KeithAK,
pubmed-author:ViozziChristopher FCF,
pubmed-author:WitzigThomas ETE,
pubmed-author:ZeldenrustSteven RSR
|
| pubmed:issnType |
Print
|
| pubmed:volume |
81
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1047-53
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16901028-Bone Density Conservation Agents,
pubmed-meshheading:16901028-Diphosphonates,
pubmed-meshheading:16901028-Humans,
pubmed-meshheading:16901028-Imidazoles,
pubmed-meshheading:16901028-Minnesota,
pubmed-meshheading:16901028-Multiple Myeloma,
pubmed-meshheading:16901028-Osteoporosis,
pubmed-meshheading:16901028-Practice Guidelines as Topic
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Mayo clinic consensus statement for the use of bisphosphonates in multiple myeloma.
|
| pubmed:affiliation |
Division of Hematology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA. lacy.martha@mayo.edu
|
| pubmed:publicationType |
Journal Article,
Review,
Consensus Development Conference
|