Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-8-11
pubmed:abstractText
Multiple sclerosis (MS) is usually a disease of young adulthood, its clinical onset occurring between 20 and 40 years of age; however, today there is general consensus that MS can also occur in children, adolescents and even in infants. In order to gain further insight into the T-cell repertoire present in this particular group of patients myelin basic protein (MBP)-, MBP exon-2- and myelin oligodendrocyte glycoprotein (MOG)Igd-specific T-cell lines (TCLs) were isolated from 18 patients whose symptoms had started before the age of 16. Epitope specificity was established by measuring proliferative responses, and interferon-y (IFN-y) secretion by using a panel of overlapping synthetic peptides. For MOGIgd, the T-cell response was focused on three main immunodominant epitopes comprising residues 1-26, 36-60 and 63-87. For MBP the predominant immune responses were directed against peptides 83-102, 139-153 and 146-162. When compared to those observed in adult-onset MS patients, anti-MOGIgd specificity and anti-MBP responses showed similar results. Moreover, the number of MBP exon-2 TCLs isolated, and the magnitude of the specific IFN-gamma secretion induced were similar, both in childhood/juvenile-onset and adult-onset MS patients. Thus, despite differences in the clinical and neuroimaging manifestations of MS, these results would seem to indicate that both the spectrum of MBP found, as well as the MOGIgd epitopes recognized by peripheral blood T cells in MS, appear to be similar for childhood/juvenile-onset and adult-onset patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1352-4585
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
412-20
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:16900754-Adolescent, pubmed-meshheading:16900754-Age of Onset, pubmed-meshheading:16900754-Cell Line, pubmed-meshheading:16900754-Child, pubmed-meshheading:16900754-Child, Preschool, pubmed-meshheading:16900754-Cohort Studies, pubmed-meshheading:16900754-Epitope Mapping, pubmed-meshheading:16900754-Epitopes, T-Lymphocyte, pubmed-meshheading:16900754-Female, pubmed-meshheading:16900754-Humans, pubmed-meshheading:16900754-Interferon-gamma, pubmed-meshheading:16900754-Male, pubmed-meshheading:16900754-Multiple Sclerosis, Relapsing-Remitting, pubmed-meshheading:16900754-Myelin Basic Proteins, pubmed-meshheading:16900754-Myelin Proteins, pubmed-meshheading:16900754-Myelin-Associated Glycoprotein, pubmed-meshheading:16900754-Peptide Fragments, pubmed-meshheading:16900754-T-Lymphocytes
pubmed:year
2006
pubmed:articleTitle
Myelin basic protein and myelin oligodendrocyte glycoprotein T-cell repertoire in childhood and juvenile multiple sclerosis.
pubmed:affiliation
Department of Neurology, Raúl Carrea Institute for Neurological Research, (FLENI), Montañeses 2325 (1428), Buenos Aires, Argentina. jcorreale@fleni.org.ar
pubmed:publicationType
Journal Article