|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0231221,
umls-concept:C0458827,
umls-concept:C0678951,
umls-concept:C0681850,
umls-concept:C0750540,
umls-concept:C1335671,
umls-concept:C1550501,
umls-concept:C1556094,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2006-8-10
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|
pubmed:abstractText |
Nonspecific airway hyperresponsiveness (AHR), a cardinal feature of asthma, is thought to result from several genetic and environmental factors. Asymptomatic AHR in nonasthmatic healthy subjects might be a risk factor for the development of asthma. Genetic variations in codons 16 and 27 of the human beta(2)-adrenergic receptor (beta(2)-AR) alter receptor function in vitro and are associated with various asthma-related phenotypes, including asthma severity and AHR. To date, however, few reports have examined the impact of beta(2)-AR gene polymorphism on AHR in asymptomatic healthy subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0012-3692
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
449-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16899844-Administration, Inhalation,
pubmed-meshheading:16899844-Adolescent,
pubmed-meshheading:16899844-Adult,
pubmed-meshheading:16899844-Alleles,
pubmed-meshheading:16899844-Bronchial Hyperreactivity,
pubmed-meshheading:16899844-Bronchoconstriction,
pubmed-meshheading:16899844-Bronchoconstrictor Agents,
pubmed-meshheading:16899844-DNA,
pubmed-meshheading:16899844-Female,
pubmed-meshheading:16899844-Genotype,
pubmed-meshheading:16899844-Humans,
pubmed-meshheading:16899844-Japan,
pubmed-meshheading:16899844-Male,
pubmed-meshheading:16899844-Methacholine Chloride,
pubmed-meshheading:16899844-Polymerase Chain Reaction,
pubmed-meshheading:16899844-Polymorphism, Genetic,
pubmed-meshheading:16899844-Prevalence,
pubmed-meshheading:16899844-Receptors, Adrenergic, beta-2,
pubmed-meshheading:16899844-Reference Values
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pubmed:year |
2006
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pubmed:articleTitle |
Association between nonspecific airway hyperresponsiveness and Arg16Gly beta2-adrenergic receptor gene polymorphism in asymptomatic healthy Japanese subjects.
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pubmed:affiliation |
First Department of Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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