16899612

Source:http://linkedlifedata.com/resource/pubmed/id/16899612

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017102, umls-concept:C0031327, umls-concept:C0246415, umls-concept:C0993630
pubmed:issue	15
pubmed:dateCreated	2006-8-10
pubmed:abstractText	The herbal supplement garlic (Allium sativum) is commonly used by cancer patients. Preclinical studies have shown that allicin, a major component of garlic, may affect cytochrome P450 3A4 (CYP3A4) activity. This study examines the influence of garlic supplementation on the pharmacokinetics of docetaxel, a CYP3A4 substrate.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9502500
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A5 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/Taxoids, http://linkedlifedata.com/resource/pubmed/chemical/docetaxel
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	1078-0432
pubmed:author	pubmed-author:BermanArleneA, pubmed-author:CoxMichael CMC, pubmed-author:DenduluriNeelimaN, pubmed-author:FiggWilliam DWD, pubmed-author:LeeJamesJ, pubmed-author:LowJenniferJ, pubmed-author:PermenterMatthew GMG, pubmed-author:PetrosWilliam PWP, pubmed-author:PriceDouglas KDK, pubmed-author:SparreboomAlexA, pubmed-author:SwainSandra MSM, pubmed-author:WalsheJaniceJ
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4636-40
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:16899612-Adenocarcinoma, pubmed-meshheading:16899612-Administration, Oral, pubmed-meshheading:16899612-Adult, pubmed-meshheading:16899612-Aged, pubmed-meshheading:16899612-Alleles, pubmed-meshheading:16899612-Antineoplastic Agents, pubmed-meshheading:16899612-Breast Neoplasms, pubmed-meshheading:16899612-Cytochrome P-450 CYP3A, pubmed-meshheading:16899612-Cytochrome P-450 Enzyme System, pubmed-meshheading:16899612-Dose-Response Relationship, Drug, pubmed-meshheading:16899612-Drug Administration Schedule, pubmed-meshheading:16899612-Female, pubmed-meshheading:16899612-Follow-Up Studies, pubmed-meshheading:16899612-Garlic, pubmed-meshheading:16899612-Genotype, pubmed-meshheading:16899612-Humans, pubmed-meshheading:16899612-Injections, Intravenous, pubmed-meshheading:16899612-Middle Aged, pubmed-meshheading:16899612-Predictive Value of Tests, pubmed-meshheading:16899612-Prospective Studies, pubmed-meshheading:16899612-Taxoids, pubmed-meshheading:16899612-Time Factors, pubmed-meshheading:16899612-Treatment Outcome
pubmed:year	2006
pubmed:articleTitle	Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel.
pubmed:affiliation	Clinical Pharmacology Research Core, National Cancer Institute, Bethesda, Maryland 20889, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Intramural