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rdf:type |
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lifeskim:mentions |
umls-concept:C0012634,
umls-concept:C0023768,
umls-concept:C0031398,
umls-concept:C0031676,
umls-concept:C0033414,
umls-concept:C0033684,
umls-concept:C0040715,
umls-concept:C0052172,
umls-concept:C0521451,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C1522702,
umls-concept:C1524075,
umls-concept:C1709634
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pubmed:issue |
1
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pubmed:dateCreated |
1990-4-6
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pubmed:abstractText |
The interaction of phenethyl alcohol with model membranes and its effect on translocation of the chemically prepared mitochondrial precursor protein apocytochrome c across a lipid bilayer was studied. Phenethyl alcohol efficiently penetrates into monolayers and causes acyl chain disordering judged from deuterium nuclear magnetic resonance measurements with specific acyl chain-deuterated phospholipids. Translocation of apocytochrome c across a phospholipid bilayer was stimulated on addition of phenethyl alcohol indicating that the efficiency of translocation of this precursor protein is enhanced due to a disorder of the acyl chain region of the bilayer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2-dielaidoylphosphatidylethanolami...,
http://linkedlifedata.com/resource/pubmed/chemical/1,2-dioleoylphosphatidylserine,
http://linkedlifedata.com/resource/pubmed/chemical/1,2-oleoylphosphatidylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Apoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome c Group,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes c,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid Bilayers,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylethyl Alcohol,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylcholines,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylethanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylserines,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
261
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1689674-Apoproteins,
pubmed-meshheading:1689674-Biological Transport,
pubmed-meshheading:1689674-Cytochrome c Group,
pubmed-meshheading:1689674-Cytochromes c,
pubmed-meshheading:1689674-Ethanol,
pubmed-meshheading:1689674-Lipid Bilayers,
pubmed-meshheading:1689674-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1689674-Membrane Lipids,
pubmed-meshheading:1689674-Mitochondria,
pubmed-meshheading:1689674-Phenylethyl Alcohol,
pubmed-meshheading:1689674-Phosphatidylcholines,
pubmed-meshheading:1689674-Phosphatidylethanolamines,
pubmed-meshheading:1689674-Phosphatidylserines,
pubmed-meshheading:1689674-Phospholipids,
pubmed-meshheading:1689674-Protein Precursors,
pubmed-meshheading:1689674-Trypsin
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pubmed:year |
1990
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pubmed:articleTitle |
Phenethyl alcohol disorders phospholipid acyl chains and promotes translocation of the mitochondrial precursor protein apocytochrome c across a lipid bilayer.
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pubmed:affiliation |
Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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