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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
26
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pubmed:dateCreated |
2006-9-11
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pubmed:abstractText |
The marked variability of irinotecan (Ir) clearance warrants individualized dosing based on hepatic drug handling. The aims of this trial were to identify parameters from functional hepatic nuclear imaging (HNI) that correlate with (1) Ir pharmacology, and (2) single-nucleotide polymorphisms (SNPs) for the ABCB1 (P-glycoprotein) and UGT-1A1 genes, known to influence Ir handling.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Camptothecin,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Anion Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Radiopharmaceuticals,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium Tc 99m...,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium Tc 99m Disofenin,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium Tc 99m Sestamibi,
http://linkedlifedata.com/resource/pubmed/chemical/bilirubin...,
http://linkedlifedata.com/resource/pubmed/chemical/irinotecan
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:ClarkeStephen JSJ,
pubmed-author:Di IulioJuliaJ,
pubmed-author:EllisAndrewA,
pubmed-author:GurtlerVolkerV,
pubmed-author:HicksRod JRJ,
pubmed-author:HoskinsJanelle MJM,
pubmed-author:JeffordMichaelM,
pubmed-author:KeenM AMA,
pubmed-author:MilnerAlvin DAD,
pubmed-author:MitchellPaul LPL,
pubmed-author:ScottAndrew MAM,
pubmed-author:TebbutNiall CNC,
pubmed-author:ThompsonMickM,
pubmed-author:XXX,
pubmed-author:ZalcbergJohn RJR
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4228-35
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16896007-Adult,
pubmed-meshheading:16896007-Aged,
pubmed-meshheading:16896007-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:16896007-Area Under Curve,
pubmed-meshheading:16896007-Camptothecin,
pubmed-meshheading:16896007-Female,
pubmed-meshheading:16896007-Gene Frequency,
pubmed-meshheading:16896007-Genotype,
pubmed-meshheading:16896007-Glucuronosyltransferase,
pubmed-meshheading:16896007-Humans,
pubmed-meshheading:16896007-Liver,
pubmed-meshheading:16896007-Male,
pubmed-meshheading:16896007-Middle Aged,
pubmed-meshheading:16896007-Organic Anion Transporters,
pubmed-meshheading:16896007-P-Glycoprotein,
pubmed-meshheading:16896007-Pharmacogenetics,
pubmed-meshheading:16896007-Polymorphism, Single Nucleotide,
pubmed-meshheading:16896007-Radiopharmaceuticals,
pubmed-meshheading:16896007-Regression Analysis,
pubmed-meshheading:16896007-Technetium Tc 99m Diethyl-iminodiacetic Acid,
pubmed-meshheading:16896007-Technetium Tc 99m Disofenin,
pubmed-meshheading:16896007-Technetium Tc 99m Sestamibi
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pubmed:year |
2006
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pubmed:articleTitle |
Relationship of hepatic functional imaging to irinotecan pharmacokinetics and genetic parameters of drug elimination.
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pubmed:affiliation |
Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Victoria, Australia. Michael.Michael@petermac.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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