Linked Life Data

16893896

Source:http://linkedlifedata.com/resource/pubmed/id/16893896

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
39
pubmed:dateCreated
2006-9-25
pubmed:abstractText
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human hereditary hemochromatosis. Here we demonstrate that HFE and TFR2 interact in cells, that this interaction is not abrogated by disease-associated mutations of HFE and TFR2, and that TFR2 competes with TFR1 for binding to HFE. We propose a new model for the mechanism of iron status sensing that results in the regulation of iron homeostasis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
281
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
28494-8
pubmed:dateRevised
2011-4-12
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.
pubmed:affiliation
Harvard Medical School, Children's Hospital Boston, Division of Hematology/Oncology and Howard Hughes Medical Institute, Boston, Massachusetts 02115-5737, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural