Linked Life Data

16893697

Source:http://linkedlifedata.com/resource/pubmed/id/16893697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-8-8
pubmed:abstractText
We assessed the incidence, correlates, and outcomes of acute renal failure (ARF) after thoracic aortic stent-graft placement. Postprocedural ARF is an inherent complication of catheter-based interventional procedures that use intra-arterial contrast agents and has adverse effects on short- and long-term outcomes. However, few data exist on the incidence, predictors, and outcomes of ARF after thoracic aortic stent-graft placement. We analyzed data of 97 patients (64.4 +/- 11.6 years of age; 73% men) who underwent thoracic aortic stent-graft placement from July 1999 to October 2005. Postprocedural ARF was defined as an increase > or = 25% and/or > or = 0.5 mg/dl in preprocedural serum creatinine at 48 hours after the procedure. Baseline estimated glomerular filtration rate was 65 +/- 24 ml/min/1.73 m2. Chronic kidney disease (glomerular filtration rate < or = 60 ml/min/1.73 m2) at baseline was present in 45% of patients. During the stent-graft procedure, patients received 307 +/- 188 ml of nonionic contrast medium. Postprocedural ARF occurred in 33 patients (34%), and 3 required dialysis. Multivariable analysis identified American Society of Anesthesiologists class > 3 (odds ratio 5.53, 95% confidence interval 1.71 to 17.85, p = 0.004) and duration of the stent-graft procedure (odds ratio 1.01, 95% confidence interval 1.001 to 1.014, p = 0.022) as independent predictors of postprocedural ARF. Compared with patients without ARF, those with ARF had markedly higher 30-day (18.2 +/- 6.7% vs 1.6 +/- 1.6%, p = 0.0022) and 1-year (35.2 +/- 8.6% vs 10.1 +/- 3.9%, p = 0.001) mortality. In conclusion, postprocedural ARF is a frequent complication of thoracic aortic stent-graft placement and has a significant adverse effect on 30-day and 1-year survival. Baseline factors identified in our study as associated with increased risk of ARF may facilitate a comprehensive informed consent process by way of patient education. In addition, identification of an at-risk subset may allow modification of reversible periprocedural factors that may help decrease postprocedural ARF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0002-9149
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
458-63
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:16893697-Acute Kidney Injury, pubmed-meshheading:16893697-Adult, pubmed-meshheading:16893697-Aged, pubmed-meshheading:16893697-Aged, 80 and over, pubmed-meshheading:16893697-Aortic Aneurysm, Thoracic, pubmed-meshheading:16893697-Blood Vessel Prosthesis Implantation, pubmed-meshheading:16893697-Female, pubmed-meshheading:16893697-Follow-Up Studies, pubmed-meshheading:16893697-Germany, pubmed-meshheading:16893697-Glomerular Filtration Rate, pubmed-meshheading:16893697-Humans, pubmed-meshheading:16893697-Incidence, pubmed-meshheading:16893697-Male, pubmed-meshheading:16893697-Middle Aged, pubmed-meshheading:16893697-Odds Ratio, pubmed-meshheading:16893697-Postoperative Complications, pubmed-meshheading:16893697-Prognosis, pubmed-meshheading:16893697-Retrospective Studies, pubmed-meshheading:16893697-Stents, pubmed-meshheading:16893697-Survival Rate
pubmed:year
2006
pubmed:articleTitle
Frequency and outcomes of acute renal failure following thoracic aortic stent-graft placement.
pubmed:affiliation
The Department of Cardiology, West-German Heart Center Essen, Essen, Germany. holger.eggebrecht@uni-essen.de
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't